[HTML][HTML] The 2019 US medical genetics workforce: a focus on clinical genetics

…, CA Polito, DR Maiese, AS Keehn, M Lyon, MJ Edick… - Genetics in …, 2021 - Elsevier
Purpose This study characterizes the US clinical genetics workforce to inform workforce
planning and public policy development. Methods A 32-question survey was electronically …

Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database

LDM Pena, SC van Calcar, J Hansen, MJ Edick… - Molecular genetics and …, 2016 - Elsevier
Very long chain acyl-CoA dehydrogenase (VLCAD) deficiency can present at various ages
from the neonatal period to adulthood, and poses the greatest risk of complications during …

Etoposide induces chimeric Mll gene fusions

JG Blanco, MJ Edick, MV Relling - The FASEB journal, 2004 - Wiley Online Library
MLL gene fusions are the hallmark of more than 70% of therapy‐related leukemias (t‐ML)
associated with topoisomerase II inhibitors (eg, etoposide) and cause leukemia in murine …

Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase …

MJ Edick, L Tesfay, LE Lamb… - Molecular biology of …, 2007 - Am Soc Cell Biol
In vivo in the prostate gland, basal epithelial cells adhere to laminin 5 (LM5) via α3β1 and
α6β4 integrins. When placed in culture primary prostate basal epithelial cells secrete and …

Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies

JG Blanco, MJ Edick, ML Hancock… - Pharmacogenetics …, 2002 - journals.lww.com
Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-ML) are serious
complications that affect some patients after acute lymphoblastic leukemia (ALL) treatment. …

PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5

…, GL Rosner, CH Pui, JG Blanco, MJ Edick… - Pharmacological …, 2004 - ASPET
Gene Ontology Terms: GO: 0004497 monooxygenase activity, GO: 0005783 endoplasmic
reticulum, GO: 0005792 microsome, GO: 0006118 electron transport, GO: 0008202 steroid …

Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics

C Hartford, E Vasquez, M Schwab, MJ Edick, JE Rehg… - Cancer research, 2007 - AACR
The recessive deficiency in thiopurine methyltransferase (TPMT), caused by germ-line
polymorphisms in TPMT, can cause severe toxicity after mercaptopurine. However, the …

Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis

PL Berger, SB Frank, VV Schulz, EA Nollet, MJ Edick… - Cancer research, 2014 - AACR
The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer
development are poorly understood. We identified the chromatin remodeling protein, ING4, as a …

Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

JG Blanco, T Dervieux, MJ Edick… - Proceedings of the …, 2001 - National Acad Sciences
Therapy-related acute myeloid leukemias (t-AML) with translocations of the MLL gene are
associated with the use of topoisomerase II inhibitors. We established the emergence of the …

Lymphoid gene expression as a predictor of risk of secondary brain tumors

MJ Edick, C Cheng, W Yang, M Cheok… - Genes …, 2005 - Wiley Online Library
Gene expression profiles are tissue‐specific but may also reflect germ‐line‐driven expression
patterns across tissue types. Previously, using a targeted pharmacologic approach, we …