[HTML][HTML] The 2019 US medical genetics workforce: a focus on clinical genetics
…, CA Polito, DR Maiese, AS Keehn, M Lyon, MJ Edick… - Genetics in …, 2021 - Elsevier
Purpose This study characterizes the US clinical genetics workforce to inform workforce
planning and public policy development. Methods A 32-question survey was electronically …
planning and public policy development. Methods A 32-question survey was electronically …
Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database
LDM Pena, SC van Calcar, J Hansen, MJ Edick… - Molecular genetics and …, 2016 - Elsevier
Very long chain acyl-CoA dehydrogenase (VLCAD) deficiency can present at various ages
from the neonatal period to adulthood, and poses the greatest risk of complications during …
from the neonatal period to adulthood, and poses the greatest risk of complications during …
Etoposide induces chimeric Mll gene fusions
JG Blanco, MJ Edick, MV Relling - The FASEB journal, 2004 - Wiley Online Library
MLL gene fusions are the hallmark of more than 70% of therapy‐related leukemias (t‐ML)
associated with topoisomerase II inhibitors (eg, etoposide) and cause leukemia in murine …
associated with topoisomerase II inhibitors (eg, etoposide) and cause leukemia in murine …
Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase …
MJ Edick, L Tesfay, LE Lamb… - Molecular biology of …, 2007 - Am Soc Cell Biol
In vivo in the prostate gland, basal epithelial cells adhere to laminin 5 (LM5) via α3β1 and
α6β4 integrins. When placed in culture primary prostate basal epithelial cells secrete and …
α6β4 integrins. When placed in culture primary prostate basal epithelial cells secrete and …
Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies
JG Blanco, MJ Edick, ML Hancock… - Pharmacogenetics …, 2002 - journals.lww.com
Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-ML) are serious
complications that affect some patients after acute lymphoblastic leukemia (ALL) treatment. …
complications that affect some patients after acute lymphoblastic leukemia (ALL) treatment. …
PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5
…, GL Rosner, CH Pui, JG Blanco, MJ Edick… - Pharmacological …, 2004 - ASPET
Gene Ontology Terms: GO: 0004497 monooxygenase activity, GO: 0005783 endoplasmic
reticulum, GO: 0005792 microsome, GO: 0006118 electron transport, GO: 0008202 steroid …
reticulum, GO: 0005792 microsome, GO: 0006118 electron transport, GO: 0008202 steroid …
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics
C Hartford, E Vasquez, M Schwab, MJ Edick, JE Rehg… - Cancer research, 2007 - AACR
The recessive deficiency in thiopurine methyltransferase (TPMT), caused by germ-line
polymorphisms in TPMT, can cause severe toxicity after mercaptopurine. However, the …
polymorphisms in TPMT, can cause severe toxicity after mercaptopurine. However, the …
Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis
The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer
development are poorly understood. We identified the chromatin remodeling protein, ING4, as a …
development are poorly understood. We identified the chromatin remodeling protein, ING4, as a …
Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia
JG Blanco, T Dervieux, MJ Edick… - Proceedings of the …, 2001 - National Acad Sciences
Therapy-related acute myeloid leukemias (t-AML) with translocations of the MLL gene are
associated with the use of topoisomerase II inhibitors. We established the emergence of the …
associated with the use of topoisomerase II inhibitors. We established the emergence of the …
Lymphoid gene expression as a predictor of risk of secondary brain tumors
Gene expression profiles are tissue‐specific but may also reflect germ‐line‐driven expression
patterns across tissue types. Previously, using a targeted pharmacologic approach, we …
patterns across tissue types. Previously, using a targeted pharmacologic approach, we …