User profiles for M. Leid
Mark LeidWashington State University Verified email at wsu.edu Cited by 13474 |
International union of pharmacology. LXIII. Retinoid X receptors
The physiological effects of retinoic acids (RAs) are mediated by members of two families of
nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), …
nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), …
International union of pharmacology. LX. Retinoic acid receptors
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα,
RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important …
RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important …
Multiplicity generates diversity in the retinoic acid signalling pathways
M Leid, P Kastner, P Chambon - Trends in biochemical sciences, 1992 - Elsevier
… (a) Comparison of the amino acid sequences of human (h) RARcą~, [~2 and ~'1 isoforms,
and of these receptors with their mouse (m) counterparts. The amino acid positions …
and of these receptors with their mouse (m) counterparts. The amino acid positions …
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Calorie restriction extends lifespan in organisms ranging from yeast to mammals 1 . In yeast,
the SIR2 gene mediates the life-extending effects of calorie restriction 2 . Here we show that …
the SIR2 gene mediates the life-extending effects of calorie restriction 2 . Here we show that …
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
M Leid, P Kastner, R Lyons, H Nakshatri, M Saunders… - Cell, 1992 - cell.com
We have purified and cloned a HeLa cell nuclear protein that strongly stimulates binding of
retinoic acid and thyroid hormone receptors (RARs and TRs) to response elements. The …
retinoic acid and thyroid hormone receptors (RARs and TRs) to response elements. The …
Abnormal spermatogenesis in RXR beta mutant mice.
We have generated mouse lines in which the RXR beta gene was disrupted by homologous
recombination. Approximately 50% of the RXR beta homozygous mutants died before or at …
recombination. Approximately 50% of the RXR beta homozygous mutants died before or at …
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs
B Durand, M Saunders, P Leroy, M Leid, P Chambon - Cell, 1992 - cell.com
Two cooperating retinoic acid response elements (RAREs) in the cellular retinoic acid-binding
protein II (CRABPII) gene mediate differential transcriptional transactivation by retinoic …
protein II (CRABPII) gene mediate differential transcriptional transactivation by retinoic …
Detection of apoptosis by TUNEL assay
K Kyrylkova, S Kyryachenko, M Leid… - … : methods and protocols, 2012 - Springer
Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay has
been designed to detect apoptotic cells that undergo extensive DNA degradation during the …
been designed to detect apoptotic cells that undergo extensive DNA degradation during the …
An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b
L Li, M Leid, EV Rothenberg - Science, 2010 - science.org
… M. Bornert for help with generation of the floxed Bcl11b mice; H.-Y. … M. Bornert for help
with generation of the floxed Bcl11b mice; H.-Y. … Mark Leid …
with generation of the floxed Bcl11b mice; H.-Y. … Mark Leid …
Regulation of transcription factor activity by interconnected post-translational modifications
TM Filtz, WK Vogel, M Leid - Trends in pharmacological sciences, 2014 - cell.com
Transcription factors comprise just over 7% of the human proteome and serve as gatekeepers
of cellular function, integrating external signal information into gene expression programs …
of cellular function, integrating external signal information into gene expression programs …