Animal models of nociception

D Le Bars, M Gozariu, SW Cadden - Pharmacological reviews, 2001 - ASPET
The study of pain in awake animals raises ethical, philosophical, and technical problems.
We review the ethical standards for studying pain in animals and emphasize that there are …

Temporal summation of C-fiber afferent inputs: competition between facilitatory and inhibitory effects on C-fiber reflex in the rat

M Gozariu, D Bragard, JC Willer… - Journal of …, 1997 - journals.physiology.org
Gozariu, Manuela, Dominique Bragard, Jean-Claude Willer, and Daniel Le Bars. Temporal
summation of C-fiber afferent inputs: competition between facilitatory and inhibitory effects on …

An electrophysiological investigation into the monosynaptic H-reflex in the rat

M Gozariu, V Roth, F Keime, D Le Bars, JC Willer - Brain research, 1998 - Elsevier
In order to set up a non-invasive, reliable and reproducible model for investigating α-motoneuronal
activity, we studied the electrophysiological features of a monosynaptic H-reflex in …

The influence of temporal summation on a C-fibre reflex in the rat: effects of lesions in the rostral ventromedial medulla (RVM)

M Gozariu, D Bouhassira, JC Willer, D Le Bars - Brain research, 1998 - Elsevier
In intact rats, an inhibitory mechanism counteracts the increase in excitability of a flexor reflex
seen in spinal animals following high-intensity, repetitive stimulation of C-fibres. We tested …

Temporal summation and a C-fibre reflex in the rat: effects of morphine on facilitatory and inhibitory mechanisms

M Gozariu, D Bouhassira, JC Willer… - European journal of …, 2000 - Elsevier
In intact rats, an inhibitory mechanism counteracts the increase in excitability of a flexor reflex,
which is seen in spinal animals following temporal summation of C-fibre inputs; the Rostral …

Effects of ICI 118.551, a selective beta-2 adrenergic blocking agent on the guinea pig cardic excitability and ventricular fibrillation threshold

B Cuparencu, C Tomus, M Gozariu… - Acta Physiologica …, 2000 - real.mtak.hu
In isolated guinea pig perfused hearts ICI 118.551, a selective beta 2 adrenoceptor antagonist,
induced transient ventricular extrasystoles. Following the termination of the perfusion, a …

Effects of clonidine on a C-fibre reflex in the rat

M Gozariu, D Bustamante, D Le Bars… - European journal of …, 1996 - Elsevier
A C-fibre reflex elicited by electrical stimulation within the territory of the sural nerve, was
recorded from the ipsilateral biceps femoris muscle in anaesthetized rats. The temporal …

[PDF][PDF] Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.

F Guirimand, M Strimbu-Gozariu… - … of Pharmacology and …, 1994 - researchgate.net
The roles of mu, delta and kappa oploid receptor subtypes in spinal morphine-induced
antinociception were investigated. A C-fiber reflex elicited by eleCtriCal stimulation within the …

A sensitive test for studying the effects of opioids on a C-fibre reflex elicited by a wide range of stimulus intensities in the rat

M Strimbu-Gozariu, F Guirimand, JC Willer… - European journal of …, 1993 - Elsevier
A C-fibre reflex elicited by electrical stimulation within the receptive field of the sural nerve
was recorded from the ipsilateral biceps femoris muscle in anaesthetized rats. Recruitment …

Manuela Gozariu Le Bars (1962-2022)

MA D'Agostino - Medicine and Pharmacy Reports, 2023 - medpharmareports.com
In the fall of last year, prematurely and sadly, a prominent alumna of the Iuliu Hatieganu
University of Medicine and Pharmacy from Cluj-Napoca passed away: Manuela Gozariu Le Bars…