Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment
SE Bulun, Z Lin, G Imir, S Amin, M Demura… - Pharmacological …, 2005 - ASPET
A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition
of which effectively eliminates estrogen production. Aromatase inhibitors successfully …
of which effectively eliminates estrogen production. Aromatase inhibitors successfully …
High aromatase expression in uterine leiomyoma tissues of African-American women
H Ishikawa, S Reierstad, M Demura… - The Journal of …, 2009 - academic.oup.com
Context: Symptomatic uterine leiomyoma is associated with irregular uterine bleeding, anemia,
and recurrent pregnancy loss. African-American women develop uterine leiomyomas at …
and recurrent pregnancy loss. African-American women develop uterine leiomyomas at …
Cardiac aldosterone production in genetically hypertensive rats
Y Takeda, T Yoneda, M Demura, I Miyamori… - …, 2000 - Am Heart Assoc
Aldosterone is synthesized in extra-adrenal tissues, both blood vessels and brain. We
undertook the present study to determine whether the rat heart produces aldosterone and to …
undertook the present study to determine whether the rat heart produces aldosterone and to …
Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy
Y Takeda, T Yoneda, M Demura, I Miyamori… - …, 2000 - academic.oup.com
ABSTRACT High sodium intake causes cardiac hypertrophy independently of increases in
blood pressure. Aldosterone is synthesized in extra- adrenal tissues such as blood vessels, …
blood pressure. Aldosterone is synthesized in extra- adrenal tissues such as blood vessels, …
Aromatase excess in cancers of breast, endometrium and ovary
…, D Chen, M Lu, H Zhao, Y Cheng, M Demura… - The Journal of steroid …, 2007 - Elsevier
Pathogenesis and growth of three common women's cancers (breast, endometrium and ovary)
are linked to estrogen. A single gene encodes the key enzyme for estrogen biosynthesis …
are linked to estrogen. A single gene encodes the key enzyme for estrogen biosynthesis …
Impact of new quick gold nanoparticle-based cortisol assay during adrenal vein sampling for primary aldosteronism
…, M Kometani, M Usukura, M Demura… - The Journal of …, 2016 - academic.oup.com
Context: Adrenal vein sampling (AVS) is essential for identifying a surgically curable form of
primary aldosteronism (PA), but accurate placement of the sampling catheter is technically …
primary aldosteronism (PA), but accurate placement of the sampling catheter is technically …
Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy
Y Takeda, T Yoneda, M Demura, M Usukura… - Circulation, 2002 - Am Heart Assoc
Background— It remains unclear how mineralocorticoids induce cardiac hypertrophy and
fibrosis. Recently, activation of the calcium-dependent phosphatase, calcineurin, has been …
fibrosis. Recently, activation of the calcium-dependent phosphatase, calcineurin, has been …
Dynamic CCAAT/enhancer binding protein–associated changes of DNA methylation in the angiotensinogen gene
F Wang, M Demura, Y Cheng, A Zhu, S Karashima… - …, 2014 - Am Heart Assoc
DNA methylation patterns are maintained in adult somatic cells. Recent findings, however,
suggest that all methylation patterns are not preserved. We demonstrate that stimulatory …
suggest that all methylation patterns are not preserved. We demonstrate that stimulatory …
[HTML][HTML] Molecular and epigenetic control of aldosterone synthase, CYP11B2 and 11-Hydroxylase, CYP11B1
Y Takeda, M Demura, M Kometani… - International Journal of …, 2023 - mdpi.com
Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular diseases
and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by …
and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by …
Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats
Y Takeda, T Yoneda, M Demura… - Journal of …, 2001 - journals.lww.com
Objectives Aldosterone is synthesized in extra-adrenal tissues such as the vasculature, heart
and brain. The mechanisms underlying the effect of high salt intake on the development …
and brain. The mechanisms underlying the effect of high salt intake on the development …