Potassium channels: molecular defects, diseases, and therapeutic opportunities

CC Shieh, M Coghlan, JP Sullivan… - Pharmacological …, 2000 - ASPET
Potassium channels play important roles in vital cellular signaling processes in both excitable
and nonexcitable cells. Over 50 human genes encoding various K + channels have been …

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

MJ Coghlan, PB Jacobson, B Lane… - Molecular …, 2003 - academic.oup.com
Glucocorticoids (GCs) are commonly used to treat inflammatory disease; unfortunately, the
long-term use of these steroids leads to a large number of debilitating side effects. The …

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets

…, SM Gutierrez Sanfeliciano, MJ Tebbe, MJ Coghlan - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE The clinical effectiveness of parenterally-administered glucagon-like peptide-1 (GLP-1)
mimetics to improve glucose control in patients suffering from type 2 diabetes …

Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2, 5-dihydro-10-methoxy-2, 2 …

SW Elmore, MJ Coghlan, DD Anderson… - Journal of medicinal …, 2001 - ACS Publications
The preparation and characterization of a series of selective glucocorticoid receptor
modulators are described. The preliminary structure−activity relationship of nonaromatic C-5 …

Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation

AS Parihar, MJ Coghlan, M Gopalakrishnan… - European journal of …, 2003 - Elsevier
The effects of 1-ethyl-2-benzimidazolinone (1-EBIO) and riluzole on human prostate cancer
cells, LNCaP and PC-3, were evaluated using rubidium ( 86 Rb + ) efflux and proliferation …

Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress

MJ Coghlan, WA Carroll… - Journal of medicinal …, 2001 - ACS Publications
Investigation of potassium channel biology continues to be an ever-expanding field of research.
The ability of K+ channels to regulate membrane potential accords them a central role in …

Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2, 5-dihydro-2, 2, 4-trimethyl-1H …

PR Kym, ME Kort, MJ Coghlan, JL Moore… - Journal of medicinal …, 2003 - ACS Publications
The preparation and characterization of a series of C-10 substituted 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
as a novel class of selective ligands for the …

Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity

MJ Coghlan, PR Kym, SW Elmore… - Journal of medicinal …, 2001 - ACS Publications
A novel class of functional ligands for the human glucocorticoid receptor is described. Substituents
in the C-10 position of the tetracyclic core are essential for glucocorticoid receptor (GR…

Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators

…, CC Shieh, U Warrior, DJ Burns, MJ Coghlan… - SLAS Discovery, 2001 - Elsevier
A fluorescence-based assay using the FLIPR Membrane Potential Assay Kit (FMP) was
evaluated for functional characterization and high throughput screening (HTS) of potassium …

Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases

ME Coghlan, JP Sommadossi, NC Jhala… - Clinical infectious …, 2001 - academic.oup.com
We retrospectively investigated the clinical and histopathologic features of hospitalized
patients infected with human immunodeficiency virus who had symptomatic lactic acidosis …