Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins
of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) in …

Caveolae were originally identified as ffask-shaped invaginations of the plasma membrane
in endothelial and epithelial cells (14). Prior to the development of biochemical methods for …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a suspected …

Awareness that the metabolic phenotype of cells within tumours is heterogeneous — and
distinct from that of their normal counterparts — is growing. In general, tumour cells metabolize …

Among the membrane compartments of a cell, vesicles known as “caveolae” have long defied
functional characterization. However, since the identification of a family of proteins termed “…

Caveolae are plasma membrane specializations that have been implicated in signal transduction.
Caveolin, a 21-24-kDa integral membrane protein, is a principal structural component …

Endothelial nitric oxide synthase (eNOS) is a dually acylated peripheral membrane protein
that targets to the Golgi region and caveolae of endothelial cells. Recent evidence has shown …

Caveolin, a 21-24-kDa integral membrane protein, is a principal component of caveolae
membranes. We have suggested that caveolin functions as a scaffolding protein to organize …

Caveolae are 50-100-nm membrane microdomains that represent a subcompartment of the
plasma membrane. Previous morphological studies have implicated caveolae in (a) the …