User profiles for Mohammad Reza Zirak

Mohammad Reza Zirak

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad …
Verified email at mums.ac.ir
Cited by 1001

[HTML][HTML] Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review

M Zeinali, MR Zirak, SA Rezaee, G Karimi… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history
in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of …

5-HT3 receptor antagonists in neurologic and neuropsychiatric disorders: The iceberg still lies beneath the surface

…, R Rahimian, J Dyhrfjeld-Johnsen, MR Zirak… - Pharmacological …, 2019 - ASPET
5-HT 3 receptor antagonists, first introduced to the market in the mid-1980s, are proven efficient
agents to counteract chemotherapy-induced emesis. Nonetheless, recent investigations …

A novel dual-targeting delivery system for specific delivery of CRISPR/Cas9 using hyaluronic acid, chitosan and AS1411

Z Khademi, M Ramezani, M Alibolandi, MR Zirak… - Carbohydrate …, 2022 - Elsevier
A facile method was designed that can specifically deliver CRISPR/Cas9 into target cells
nuclei and reduce the off-target effects. A multifunctional delivery vector for FOXM1 knockout …

[HTML][HTML] Natural products as safeguards against monosodium glutamate-induced toxicity

MM Hajihasani, V Soheili, MR Zirak… - Iranian Journal of …, 2020 - ncbi.nlm.nih.gov
Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid,
which is widely used in food industry. Glutamate plays an important role in principal brain …

Curcumin and its analogues protect from endoplasmic reticulum stress: Mechanisms and pathways

A Shakeri, MR Zirak, AW Hayes, R Reiter… - Pharmacological …, 2019 - Elsevier
The endoplasmic reticulum (ER), a cellular organelle with multiple functions, plays an important
role in several biological processes including protein folding, secretion, lipid biosynthesis…

Novel EPR-enhanced strategies for targeted drug delivery in pancreatic cancer: An update

…, A Rahdar, MR Jaafari, S Sargazi, MR Zirak… - Journal of Drug Delivery …, 2022 - Elsevier
Pancreatic cancer (PCa) is one of the leading causes of morbidity worldwide, and theranostic
approaches are ventured. The vast stroma surrounding PCa cells has been proven to play …

Poly-γ-glutamic acid nanoparticles as adjuvant and antigen carrier system for cancer vaccination

…, N Rahiman, H Cabral, S Quader, MR Zirak… - Journal of Controlled …, 2023 - Elsevier
Vaccination is an innovative strategy for cancer treatment by leveraging various components
of the patients' immunity to boost an anti-tumor immune response. Rationally designed …

[HTML][HTML] Antidotes for aluminum phosphide poisoning–An update

A Karimani, AH Mohammadpour, MR Zirak, R Rezaee… - Toxicology reports, 2018 - Elsevier
Aluminum phosphide (AlP), an inexpensive solid fumigant, is frequently used for grain
conservation despite its alleged high toxicity. Increased utilization of AlP for agricultural and non-…

Tropisetron attenuates cisplatin-induced nephrotoxicity in mice

MR Zirak, R Rahimian, M Ghazi-Khansari… - European journal of …, 2014 - Elsevier
Nephrotoxicity is one of the most important complications of cisplatin, a potent chemotherapeutic
agent used in the treatment of various malignancies. 5-HT 3 antagonists are widely …

Crosstalk in cancer resistance and metastasis

S Norouzi, MG Valokala, F Mosaffa, MR Zirak… - Critical Reviews in …, 2018 - Elsevier
The main obstacles that lead to clinical failure in cancer treatment are the development of
resistant to chemotherapy and a rise in invasive characteristics in cancer tumor cells due to …