Pharmacological and clinical aspects of heme oxygenase
NG Abraham, A Kappas - Pharmacological reviews, 2008 - ASPET
This review is intended to stimulate interest in the effect of increased expression of heme
oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological …
oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological …
Different faces of the heme-heme oxygenase system in inflammation
FA Wagener, HD Volk, D Willis, NG Abraham… - Pharmacological …, 2003 - ASPET
The heme-heme oxygenase system has recently been recognized to possess important
regulatory properties. It is tightly involved in both physiological as well as pathophysiological …
regulatory properties. It is tightly involved in both physiological as well as pathophysiological …
Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase
…, A Verhofstad, NG Abraham, G Adema… - Blood, The Journal …, 2001 - ashpublications.org
Various pathologic conditions, such as hemorrhage, hemolysis and cell injury, are characterized
by the release of large amounts of heme. Recently, it was demonstrated that heme …
by the release of large amounts of heme. Recently, it was demonstrated that heme …
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene.
…, RD Levere, A Kappas, NG Abraham - Proceedings of the …, 1994 - National Acad Sciences
Heme oxygenase (HO) is the rate-limiting enzyme in heme catabolism and its activity is
induced by many agents, including its substrate heme, heavy metals, UV radiation, and other …
induced by many agents, including its substrate heme, heavy metals, UV radiation, and other …
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
…, Y Liu, V Dhawan, NG Abraham… - Proceedings of the …, 2001 - National Acad Sciences
Chronic hypoxia causes pulmonary hypertension with smooth muscle cell proliferation and
matrix deposition in the wall of the pulmonary arterioles. We demonstrate here that hypoxia …
matrix deposition in the wall of the pulmonary arterioles. We demonstrate here that hypoxia …
Heme oxygenase and the cardiovascular–renal system
NG Abraham, A Kappas - Free Radical Biology and Medicine, 2005 - Elsevier
Heme oxygenase (HO) has been shown to be important for attenuating the overall production
of reactive oxygen species (ROS) through its ability to degrade heme and to produce …
of reactive oxygen species (ROS) through its ability to degrade heme and to produce …
Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin …
…, LF Rodella, WS Aronow, S Ikehara, NG Abraham - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—We hypothesized that the induction of heme oxygenase (HO)-1 and increased
HO activity, which induces arterial antioxidative enzymes and vasoprotection in a mouse …
HO activity, which induces arterial antioxidative enzymes and vasoprotection in a mouse …
[HTML][HTML] Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis
…, P Shan, D Jiang, PW Noble, NG Abraham… - Journal of Biological …, 2004 - ASBMB
Heme oxygenase-1 (HO-1) is emerging as an important cytoprotective enzyme system in a
variety of injury models. To optimize future therapeutic applications of HO-1, it is necessary to …
variety of injury models. To optimize future therapeutic applications of HO-1, it is necessary to …
Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
…, S Ikehara, MS Wolin, NG Abraham - American Journal …, 2005 - journals.physiology.org
Increased heme oxygenase (HO)-1 activity attenuates endothelial cell apoptosis and decreases
superoxide anion (O 2 − ) formation in experimental diabetes by unknown mechanisms. …
superoxide anion (O 2 − ) formation in experimental diabetes by unknown mechanisms. …
Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats
D Sacerdoti, B Escalante, NG Abraham, JC McGiff… - Science, 1989 - science.org
Cytochrome P-450-dependent metabolites of arachidonic acid (AA) increased in the kidneys
of young, spontaneously hypertensive rats (SHRs) during the period of rapid elevation of …
of young, spontaneously hypertensive rats (SHRs) during the period of rapid elevation of …