Systems medicine has a mechanism-based rather than a symptom- or organ-based approach
to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In this …

The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) triggers the first line
of homeostatic responses against a plethora of environmental or endogenous deviations in …

The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) …

Neural stem/progenitor cells (NSPCs) located at the subgranular zone (SGZ) of the
hippocampus participate in the maintenance of synaptic networks that ensure cognitive functions …

Significance: Oxidative stress is suggested to be a disease mechanism common to a wide
range of disorders affecting human health. However, so far, the pharmacotherapeutic …

Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far,
has been involved in tumor progression by providing a metabolic adaptation to tumorigenic …

There is emerging evidence for the involvement of reactive oxygen species (ROS) in the
regulation of stem cells and cellular differentiation. Absence of the ROS-generating NADPH …

The transcription factor NRF2 is a master regulator of cellular antioxidant and detoxification
responses, but it also regulates other processes such as autophagy and pluripotency. In …

The mechanisms involved in regulation of quiescence, proliferation, and reprogramming of
Neural Stem Progenitor Cells (NSPCs) of the mammalian brain are still poorly defined. Here, …

Full article: Adopting a portfolio of ultrasonic and advanced bipolar electrosurgery devices
from a single manufacturer compared to currently used ultrasonic and advanced bipolar …