[PDF][PDF] Hypothalamic orexin neurons regulate arousal according to energy balance in mice
…, CT Beuckmann, JT Willie, J Hara, N Tsujino… - Neuron, 2003 - cell.com
Mammals respond to reduced food availability by becoming more wakeful and active, yet the
central pathways regulating arousal and instinctual motor programs (such as food seeking) …
central pathways regulating arousal and instinctual motor programs (such as food seeking) …
[PDF][PDF] Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice
…, R Nagata, A Yamanaka, H Kawamura, N Tsujino… - Neuron, 2005 - cell.com
The finding of orexin/hypocretin deficiency in narcolepsy patients suggests that this
hypothalamic neuropeptide plays a crucial role in regulating sleep/wakefulness states. However, …
hypothalamic neuropeptide plays a crucial role in regulating sleep/wakefulness states. However, …
Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system
N Tsujino, T Sakurai - Pharmacological reviews, 2009 - ASPET
Recent studies have implicated the orexin system as a critical regulator of sleep/wake states
as well as feeding behavior and reward processes. Orexin deficiency results in narcolepsy …
as well as feeding behavior and reward processes. Orexin deficiency results in narcolepsy …
Orexins activate histaminergic neurons via the orexin 2 receptor
A Yamanaka, N Tsujino, H Funahashi, K Honda… - Biochemical and …, 2002 - Elsevier
Orexins (orexin A and B) are recently identified neuropeptides implicated in the regulation
of vigilance states and energy homeostasis. We have shown here the physiological …
of vigilance states and energy homeostasis. We have shown here the physiological …
Orexin-induced food intake involves neuropeptide Y pathway
A Yamanaka, K Kunii, T Nambu, N Tsujino, A Sakai… - Brain research, 2000 - Elsevier
Orexins (orexin-A and -B) are recently identified neuropeptides, which are thought to be
implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist, …
implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist, …
[HTML][HTML] Role of orexin in modulating arousal, feeding, and motivation
N Tsujino, T Sakurai - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the
orexin system is particularly important for maintenance of wakefulness. However, orexin …
orexin system is particularly important for maintenance of wakefulness. However, orexin …
[HTML][HTML] Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice
Hypothalamic neurons expressing neuropeptide orexins are critically involved in the control
of sleep and wakefulness. Although the activity of orexin neurons is thought to be influenced …
of sleep and wakefulness. Although the activity of orexin neurons is thought to be influenced …
Regulation of orexin neurons by the monoaminergic and cholinergic systems
A Yamanaka, Y Muraki, N Tsujino, K Goto… - … and biophysical research …, 2003 - Elsevier
Orexins are a pair of neuropeptides implicated in energy homeostasis and arousal. Here we
characterize the electrophysiological properties of orexin neurons using slice preparations …
characterize the electrophysiological properties of orexin neurons using slice preparations …
Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor
Y Muraki, A Yamanaka, N Tsujino… - Journal of …, 2004 - Soc Neuroscience
Both orexin and serotonin (5-HT) have important roles in the regulation of sleep-wakefulness,
as well as in feeding behavior. We examined the effects of 5-HT on orexin/hypocretin …
as well as in feeding behavior. We examined the effects of 5-HT on orexin/hypocretin …
The orexin system: roles in sleep/wake regulation
The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical
regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype …
regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype …