[PDF][PDF] Hypothalamic orexin neurons regulate arousal according to energy balance in mice

…, CT Beuckmann, JT Willie, J Hara, N Tsujino… - Neuron, 2003 - cell.com
Mammals respond to reduced food availability by becoming more wakeful and active, yet the
central pathways regulating arousal and instinctual motor programs (such as food seeking) …

[PDF][PDF] Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice

…, R Nagata, A Yamanaka, H Kawamura, N Tsujino… - Neuron, 2005 - cell.com
The finding of orexin/hypocretin deficiency in narcolepsy patients suggests that this
hypothalamic neuropeptide plays a crucial role in regulating sleep/wakefulness states. However, …

Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system

N Tsujino, T Sakurai - Pharmacological reviews, 2009 - ASPET
Recent studies have implicated the orexin system as a critical regulator of sleep/wake states
as well as feeding behavior and reward processes. Orexin deficiency results in narcolepsy …

Orexins activate histaminergic neurons via the orexin 2 receptor

A Yamanaka, N Tsujino, H Funahashi, K Honda… - Biochemical and …, 2002 - Elsevier
Orexins (orexin A and B) are recently identified neuropeptides implicated in the regulation
of vigilance states and energy homeostasis. We have shown here the physiological …

Orexin-induced food intake involves neuropeptide Y pathway

A Yamanaka, K Kunii, T Nambu, N Tsujino, A Sakai… - Brain research, 2000 - Elsevier
Orexins (orexin-A and -B) are recently identified neuropeptides, which are thought to be
implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist, …

[HTML][HTML] Role of orexin in modulating arousal, feeding, and motivation

N Tsujino, T Sakurai - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the
orexin system is particularly important for maintenance of wakefulness. However, orexin …

[HTML][HTML] Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

K Sasaki, M Suzuki, M Mieda, N Tsujino, B Roth… - PloS one, 2011 - journals.plos.org
Hypothalamic neurons expressing neuropeptide orexins are critically involved in the control
of sleep and wakefulness. Although the activity of orexin neurons is thought to be influenced …

Regulation of orexin neurons by the monoaminergic and cholinergic systems

A Yamanaka, Y Muraki, N Tsujino, K Goto… - … and biophysical research …, 2003 - Elsevier
Orexins are a pair of neuropeptides implicated in energy homeostasis and arousal. Here we
characterize the electrophysiological properties of orexin neurons using slice preparations …

Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor

Y Muraki, A Yamanaka, N Tsujino… - Journal of …, 2004 - Soc Neuroscience
Both orexin and serotonin (5-HT) have important roles in the regulation of sleep-wakefulness,
as well as in feeding behavior. We examined the effects of 5-HT on orexin/hypocretin …

The orexin system: roles in sleep/wake regulation

T Sakurai, M Mieda, N Tsujino - … of the New York Academy of …, 2010 - Wiley Online Library
The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical
regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype …