Dual role of Toll-like receptors in asthma and chronic obstructive pulmonary disease

…, J Van Bergenhenegouwen, NA Georgiou… - Pharmacological …, 2012 - ASPET
During the last decade, significant research has been focused on Toll-like receptors (TLRs)
in the pathogenesis of airway diseases. TLRs are pattern recognition receptors that play …

[HTML][HTML] Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma

…, J van Bergenhenegouwen, L Boon, NA Georgiou… - Respiratory …, 2014 - Springer
Background Asthma is estimated to affect as many as 300 million people worldwide and its
incidence and prevalence are rapidly increasing throughout the world, especially in children …

Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin

NA Georgiou, T van der Bruggen… - The Journal of …, 2000 - academic.oup.com
Replication of human immunodeficiency virus type 1 (HIV-1) can be influenced by iron.
Hence, decreasing the availability of iron may inhibit HIV-1 replication. Deferoxamine and …

Pharma–nutrition interface: The gap is narrowing

NA Georgiou, J Garssen, RF Witkamp - European journal of pharmacology, 2011 - Elsevier
The interaction between pharmacology and nutrition science is on the rise. Nutritional status
is considered one of the important determinants of health and disease and several diseases …

[HTML][HTML] The combination of Bifidobacterium breve with non-digestible oligosaccharides suppresses airway inflammation in a murine model for chronic asthma

…, AP Vos, ME Morgan, J Garssen, NA Georgiou… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Over the last decade, there has been a growing interest in the use of interventions that
target the intestinal microbiota as a treatment approach for asthma. This study is aimed at …

Endothelial activation and induction of monocyte adhesion by nontransferrin‐bound iron present in human sera

AER Kartikasari, NA Georgiou, FLJ Visseren… - The FASEB …, 2006 - Wiley Online Library
Nontransferrin‐bound iron (NTBI) has been detected in iron overload diseases. This form of
iron may exert pro‐oxidant effects and modulate cellular function and inflammatory response…

Intracellular labile iron modulates adhesion of human monocytes to human endothelial cells

AER Kartikasari, NA Georgiou… - … , and vascular biology, 2004 - Am Heart Assoc
Objective— Elevated iron stores and high plasma iron concentration have been linked to an
increased risk of atherosclerosis. Iron may thereby affect the interaction of monocytes to …

Non–transferrin-bound iron and risk of coronary heart disease in postmenopausal women

…, JJM Marx, DE Grobbee, MH Kamphuis, NA Georgiou… - Circulation, 2006 - Am Heart Assoc
Background— Epidemiological studies aimed at correlating coronary heart disease (CHD)
with serum ferritin levels have thus far yielded inconsistent results. We hypothesized that a …

Intracellular labile iron promotes firm adhesion of human monocytes to endothelium under flow and transendothelial migration: iron and monocyte–endothelial cell …

…, BS van Asbeck, LH Ulfman, NA Georgiou - Atherosclerosis, 2009 - Elsevier
Monocyte infiltration across the endothelium is part of the innate immune response, however
it may contribute to severity of chronic conditions. We have investigated the effects of iron …

Impact of oral iron challenges on circulating non-transferrin-bound iron in healthy Guatemalan males

…, S Kroll, ME Romero-Abal, NA Georgiou… - Annals of Nutrition and …, 2012 - karger.com
Introduction: Oral iron as a supplement has been associated with adverse health consequences,
especially in the context of young children with active malaria. A potential aggravating …