User profiles for P. L. Chazot

Paul Chazot

Verified email at durham.ac.uk
Cited by 8515

International union of basic and clinical pharmacology. XCVIII. Histamine receptors

P Panula, PL Chazot, M Cowart, R Gutzmer… - Pharmacological …, 2015 - ASPET
Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

[HTML][HTML] Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics

…, MF Mahomoodally, D Lobine, PL Chazot… - Journal of Clinical …, 2020 - mdpi.com
Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and
Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have …

Molecular and biochemical pharmacology of the histamine H4 receptor

R Leurs, PL Chazot, FC Shenton… - British journal of …, 2009 - Wiley Online Library
The elucidation of the human genome has had a major impact on histamine receptor research.
The identification of the human H 4 receptor by several groups has been instrumental for …

The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS

…, RLM Faull, G Lees, PL Chazot - British journal of …, 2009 - Wiley Online Library
Background and purpose: The histamine H 4 receptor is the most recently identified of the G
protein‐coupled histamine receptor family and binds several neuroactive drugs, including …

Molecular dissection of native mammalian forebrain NMDA receptors containing the NR1 C2 exon: direct demonstration of NMDA receptors comprising NR1, NR2A …

PL Chazot, FA Stephenson - Journal of neurochemistry, 1997 - Wiley Online Library
… The NR2A antiserum was from Chemicon International, Temecula, CA, USA The anti-NMDA
receptor peptide antibodies were as in Chazot et al. (1992; anti-NR1 911—920 antibodies, …

Histamine, histamine receptors, and neuropathic pain relief

…, V Telezhkin, I Alrashdi, PL Chazot - British Journal of …, 2020 - Wiley Online Library
… Supported by the funding from the Medical Research Council Confidence in Concept
scheme to Drs PL Chazot and I. Obara (MC/PC/17157). We acknowledge Drs Janet Chazot and …

Preclinical animal anxiety research–flaws and prejudices

A Ennaceur, PL Chazot - Pharmacology research & …, 2016 - Wiley Online Library
The current tests of anxiety in mice and rats used in preclinical research include the elevated
plus‐maze ( EPM ) or zero‐maze ( EZM ), the light/dark box ( LDB ), and the open‐field ( OF …

Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: effects of low infrared light

…, A Ennaceur, R van Rensburg, PL Chazot - Neurobiology of learning …, 2008 - Elsevier
Non-thermal near infra-red (IR) has been shown to have many beneficial photobiological
effects on a range of cell types, including neurons. In the present study, a pretreatment with a …

Histamine pharmacology and new CNS drug targets

E Tiligada, K Kyriakidis, PL Chazot… - CNS neuroscience & …, 2011 - Wiley Online Library
During the last decade, the identification of a number of novel drug targets led to the
development of promising new compounds which are currently under evaluation for their …

Models of anxiety: responses of rats to novelty in an open space and an enclosed space

A Ennaceur, S Michalikova, PL Chazot - Behavioural brain research, 2006 - Elsevier
Exposure to novelty has been shown to induce anxiety responses in a variety of behavioural
paradigms. The purpose of the present study was to investigate whether exposition of naïve …