User profiles for P. Ghezzi
Pietro GhezziUniv Urbino. Emeritus Prof, Brighton & Sussex Med School Verified email at bsms.ac.uk Cited by 39264 |
Clinical relevance of biomarkers of oxidative stress
Significance: Oxidative stress is considered to be an important component of various diseases.
A vast number of methods have been developed and used in virtually all diseases to …
A vast number of methods have been developed and used in virtually all diseases to …
[HTML][HTML] Erythropoietin as an antiapoptotic, tissue-protective cytokine
P Ghezzi, M Brines - Cell death & differentiation, 2004 - nature.com
Erythropoietin (EPO) increases the number of circulating erythrocytes primarily by preventing
apoptosis of erythroid progenitors. In addition to this proerythroid action, results of recent …
apoptosis of erythroid progenitors. In addition to this proerythroid action, results of recent …
Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Systems medicine has a mechanism-based rather than a symptom- or organ-based approach
to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In this …
to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In this …
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
…, A Cerami, H Ehrenreich, P Ghezzi - Proceedings of the …, 2001 - National Acad Sciences
… P < 0.05 indicates statistical significance as compared with control; •, P < 0.05 denotes
statistical significance as compared with EPO during serum withdrawal or kainate treatment.) …
statistical significance as compared with EPO during serum withdrawal or kainate treatment.) …
[PDF][PDF] Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
…, C Toniatti, N Polentarutti, P Fruscella, P Ghezzi… - Immunity, 1997 - cell.com
IL-6 −/− mice showed impaired leukocyte accumulation in subcutaneous air pouches.
Defective leukocyte accumulation was not due to a reduced migratory capacity of IL-6 −/− …
Defective leukocyte accumulation was not due to a reduced migratory capacity of IL-6 −/− …
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
ML Brines, P Ghezzi, S Keenan… - Proceedings of the …, 2000 - National Acad Sciences
Erythropoietin (EPO), recognized for its central role in erythropoiesis, also mediates neuroprotection
when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain…
when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain…
Derivatives of erythropoietin that are tissue protective but not erythropoietic
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction
with different receptors. We generated receptor subtype–selective ligands allowing the …
with different receptors. We generated receptor subtype–selective ligands allowing the …
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
…, L Leng, T Kooistra, G Fingerle-Rowson, P Ghezzi… - Nature medicine, 2007 - nature.com
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory
diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as …
diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as …
Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling
…, A Leri, P Anversa, P Ghezzi… - Proceedings of the …, 2003 - National Acad Sciences
Erythropoietin (EPO), originally identified for its critical hormonal role in promoting erythrocyte
survival and differentiation, is a member of the large and diverse cytokine superfamily. …
survival and differentiation, is a member of the large and diverse cytokine superfamily. …
Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
…, A Cerami, TR Coleman, M Brines, P Ghezzi - The Journal of …, 2003 - rupress.org
… P < 0.05; **, P <0.01 versus ischemia plus PBS by Student's t test. Cytokine levels in the
contralateral cortex were below the limit of detection (TNF < 1 U/g tissue; IL-6 < 150 U/g; MCP-1 …
contralateral cortex were below the limit of detection (TNF < 1 U/g tissue; IL-6 < 150 U/g; MCP-1 …