Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in …
…, D Hallifax, HS Brown, P Maurel… - Drug metabolism …, 2007 - Taylor & Francis
This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …
The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors
…, S Gerbal-Chaloin, L Drocourt, P Maurel… - … et Biophysica Acta (BBA …, 2003 - Elsevier
Numerous chemicals increase the metabolic capability of organisms by their ability to activate
genes encoding various xenochemical-metabolizing enzymes, such as cytochromes P450 …
genes encoding various xenochemical-metabolizing enzymes, such as cytochromes P450 …
The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences
…, MJ Vilarem, P Maurel - Annu. Rev …, 2008 - annualreviews.org
The expression of many genes involved in xenobiotic/drug metabolism and transport is
regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), …
regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), …
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid
levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum …
levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum …
[HTML][HTML] Expression of cyp3a4, cyp2b6, andcyp2c9 is regulated by the vitamin d receptor pathway in primary human hepatocytes
L Drocourt, JC Ourlin, JM Pascussi, P Maurel… - Journal of Biological …, 2002 - ASBMB
The fully active dihydroxylated metabolite of vitamin D 3 induces the expression ofCYP3A4
and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human …
and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human …
Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X …
JM Pascussi, L Drocourt, JM Fabre, P Maurel… - Molecular …, 2000 - ASPET
In this report we show that submicromolar concentrations of dexamethasone enhance
pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human …
pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human …
[HTML][HTML] Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug-induced osteomalacia
…, T Pineau, J Saric, F Navarro, P Maurel… - The Journal of …, 2005 - Am Soc Clin Investig
Vitamin D controls calcium homeostasis and the development and maintenance of bones
through vitamin D receptor activation. Prolonged therapy with rifampicin or phenobarbital has …
through vitamin D receptor activation. Prolonged therapy with rifampicin or phenobarbital has …
The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus
…, J Coste, JM Fabre, A Sa-Cunha, P Maurel - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: The direct implication of low-density lipoprotein receptor (LDLR) in
hepatitis C virus (HCV) infection of human hepatocyte has not been demonstrated. Normal …
hepatitis C virus (HCV) infection of human hepatocyte has not been demonstrated. Normal …
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants
The pregnane X receptor (PXR)/steroid and xenobiotic receptor (SXR) transcriptionally activates
cytochrome P4503A4 (CYP3A4) when ligand activated by endobiotics and xenobiotics. …
cytochrome P4503A4 (CYP3A4) when ligand activated by endobiotics and xenobiotics. …
Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes: Sequential role of glucocorticoid receptor and pregnane X receptor
…, S Gerbal‐Chaloin, JM Fabre, P Maurel… - European journal of …, 2001 - Wiley Online Library
… [α- 32 P]dCTP, [α- 32 P]UTP and ECL developing reagents were purchased from Amersham…
dexamethasone with p(CYP3A4/XREM/–262/+11)-LUC (3.5-fold induction) and p(CYP3A4/–…
dexamethasone with p(CYP3A4/XREM/–262/+11)-LUC (3.5-fold induction) and p(CYP3A4/–…