Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in …

…, D Hallifax, HS Brown, P Maurel… - Drug metabolism …, 2007 - Taylor & Francis
This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors

…, S Gerbal-Chaloin, L Drocourt, P Maurel… - … et Biophysica Acta (BBA …, 2003 - Elsevier
Numerous chemicals increase the metabolic capability of organisms by their ability to activate
genes encoding various xenochemical-metabolizing enzymes, such as cytochromes P450 …

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences

…, MJ Vilarem, P Maurel - Annu. Rev …, 2008 - annualreviews.org
The expression of many genes involved in xenobiotic/drug metabolism and transport is
regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), …

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

…, PB Watkins, A Daly, SA Wrighton, SD Hall, P Maurel… - Nature …, 2001 - nature.com
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid
levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum …

[HTML][HTML] Expression of cyp3a4, cyp2b6, andcyp2c9 is regulated by the vitamin d receptor pathway in primary human hepatocytes

L Drocourt, JC Ourlin, JM Pascussi, P Maurel… - Journal of Biological …, 2002 - ASBMB
The fully active dihydroxylated metabolite of vitamin D 3 induces the expression ofCYP3A4
and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human …

Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X …

JM Pascussi, L Drocourt, JM Fabre, P Maurel… - Molecular …, 2000 - ASPET
In this report we show that submicromolar concentrations of dexamethasone enhance
pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human …

[HTML][HTML] Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug-induced osteomalacia

…, T Pineau, J Saric, F Navarro, P Maurel… - The Journal of …, 2005 - Am Soc Clin Investig
Vitamin D controls calcium homeostasis and the development and maintenance of bones
through vitamin D receptor activation. Prolonged therapy with rifampicin or phenobarbital has …

The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus

…, J Coste, JM Fabre, A Sa-Cunha, P Maurel - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: The direct implication of low-density lipoprotein receptor (LDLR) in
hepatitis C virus (HCV) infection of human hepatocyte has not been demonstrated. Normal …

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

…, PB Watkins, A Daly, SD Hall, P Maurel… - Pharmacogenetics …, 2001 - journals.lww.com
The pregnane X receptor (PXR)/steroid and xenobiotic receptor (SXR) transcriptionally activates
cytochrome P4503A4 (CYP3A4) when ligand activated by endobiotics and xenobiotics. …

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes: Sequential role of glucocorticoid receptor and pregnane X receptor

…, S Gerbal‐Chaloin, JM Fabre, P Maurel… - European journal of …, 2001 - Wiley Online Library
… [α- 32 P]dCTP, [α- 32 P]UTP and ECL developing reagents were purchased from Amersham…
dexamethasone with p(CYP3A4/XREM/–262/+11)-LUC (3.5-fold induction) and p(CYP3A4/–…