International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits

…, RA North, P Séguéla, M Voigt, PPA Humphrey - Pharmacological …, 2001 - ASPET
ATP acts as a humoral mediator to control cell function extracellularly. The receptors that
mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the …

Classification and nomenclature of somatostatin receptors

…, J Epelbaum, W Feniuk, PPA Humphrey… - Trends in …, 1995 - cell.com
There is considerable controversy about the classification and nomenclature of
somatostatin receptors. To date, five distinct receptor genes have been cloned and named …

A proposed new nomenclature for 5-HT receptors

PPA Humphrey, P Hartig, D Hoyer - Trends in pharmacological sciences, 1993 - cell.com
There is a continued and growing interest in the classification of 5-HT receptors, partly because
of the enormous potential for exploiting this information in terms of drug discovery’ and …

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

…, G Engel, W Feniuk, JR Fozard, PPA Humphrey… - …, 1986 - Elsevier
As a result of controversy in the literature regarding the classification and nomenclature of
functional receptors for 5-hydroxytryptamine (5-HT), a framework for classification is proposed. …

Blockade of Human P2X7 Receptor Function With a Monoclonal Antibody

…, MH Kosco-Vilbois, PPA Humphrey - Blood, The Journal …, 1998 - ashpublications.org
A monoclonal antibody (MoAb) specific for the human P2X 7 receptor was generated in mice.
As assessed by flow cytometry, the MoAb labeled human blood-derived macrophage cells …

Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature

GR Martin, PPA Humphrey - Neuropharmacology, 1994 - Elsevier
With the increasing number of 5-HT receptors recently identified, using molecular biology
techniques, the classification of 5-HT receptors is under review. An integrated approach is …

Cloning and functional characterisation of the mouse P2X7 receptor

…, AD Michel, EA Barnard, PPA Humphrey - FEBS …, 1998 - Wiley Online Library
We have isolated a 1785‐bp complementary DNA (cDNA) encoding the murine P2X 7
receptor subunit from NTW8 mouse microglial cells. The encoded protein has 80% and 85% …

Pharmacological characterization of ATP‐and LPS‐induced IL‐1β release in human monocytes

…, AD Michel, IP Chessell, PPA Humphrey - British journal of …, 1999 - Wiley Online Library
We have utilized the human monocytic cell line, THP‐1, and freshly isolated adherent
human monocytes with the compounds pyridoxalphosphate‐6‐azophenyl‐2′,4′‐disuphonic …

Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes

PR Hartig, D Hoyer, PPA Humphrey… - Trends in pharmacological …, 1996 - cell.com
As the pharmacological community moves towards obtaining a consensus on the criteria
used to systematically ctassify receptors and ion channeW it has become clear that …

Preclinical studies on the anti-migraine drug, sumatriptan

PPA Humphrey, W Feniuk, AS Marriott… - European …, 1991 - karger.com
Sumatriptan is believed to constrict selectively the cranial vessels that are distended and
inflamed during migraine. The action is mediated by activation of a 5-HT 1 receptor subtype …