Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and
Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have …

The subunit compositions of the NR1 C2 exon‐containing N‐methyl‐d‐aspartate (NMDA)
receptors of adult mammalian forebrain were determined by using a combination of …

The elucidation of the human genome has had a major impact on histamine receptor research.
The identification of the human H 4 receptor by several groups has been instrumental for …

… Supported by the funding from the Medical Research Council Confidence in Concept
scheme to Drs PL Chazot and I. Obara (MC/PC/17157). We acknowledge Drs Janet Chazot and …

The current tests of anxiety in mice and rats used in preclinical research include the elevated
plus‐maze ( EPM ) or zero‐maze ( EZM ), the light/dark box ( LDB ), and the open‐field ( OF …

During the last decade, the identification of a number of novel drug targets led to the
development of promising new compounds which are currently under evaluation for their …

The NMDAR2B subunit is the focus of increasing interest as a therapeutic target in a wide
range of CNS pathologies, including acute and chronic pain, stroke and head trauma, drug-…

The N-methyl-D-aspartate R1 (NMDA R1), NMDA R2A, and NMDA R2C subunits were
expressed transiently in double or triple combinations in human embryonic kidney (HEK) 293 …

Activation of histamine H 3 receptors (H 3 Rs) reduces inflammation and nociception, but the
existence of H 3 Rs on peripheral innervation has never been demonstrated. Here we use …