User profiles for R. E. Presby

Rose Presby

Postdoc, The Scintillon Institute
Verified email at scintillon.org
Cited by 474

The psychopharmacology of effort-related decision making: dopamine, adenosine, and insights into the neurochemistry of motivation

…, S Ferrigno, JH Yang, RA Rotolo, RE Presby - Pharmacological …, 2018 - ASPET
Effort-based decision making is studied using tasks that offer choices between high-effort
options leading to more highly valued reinforcers versus low-effort/low-reward options. These …

Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: exertion of effort vs. anhedonia

…, A Ecevitoglu, C Carratala-Ros, RE Presby… - Brain Research …, 2022 - Elsevier
Instrumental behavior is a very complex and multifaceted process. Behavioral output during
instrumental performance is influenced by a variety of factors, including associative …

Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors

…, KR Beard, C Carratala-Ros, RE Presby… - …, 2024 - nature.com
People with depression and other neuropsychiatric disorders can experience motivational
dysfunctions such as fatigue and anergia, which involve reduced exertion of effort in goal-…

[HTML][HTML] The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and …

…, F Caria, R Schwartz, RE Presby… - Frontiers in …, 2019 - frontiersin.org
Presby Rose E. Presby 1 Jen-Hau Yang Jen-Hau Yang 1 Shanna Samels Shanna Samels
1 Merce Correa, Merce Correa 1,6 Gert Lubec* Gert Lubec 7* John D. Salamone* John D. …

Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and …

RA Rotolo, P Kalaba, V Dragacevic, RE Presby… - …, 2020 - Springer
Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may
be useful for treating motivational symptoms of depression and other disorders. Previous …

Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer …

JH Yang, RE Presby, AA Jarvie, RA Rotolo… - …, 2020 - Springer
… Experiment 4: Re-examination of the effects of haloperidol on FR1/choice task … Mice were
re-trained on FR1/choice task for 1 week, and received vehicle and highest dose of haloperidol …

Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort‐related choice responding

…, RA Rotolo, GA Edelstein, RE Presby… - Journal of the …, 2022 - Wiley Online Library
The dopamine‐depleting agent tetrabenazine alters effort‐based choice, suppressing food‐reinforced
behaviors with high response requirements, while increasing selection of low‐…

The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions …

RA Rotolo, RE Presby, O Tracy, S Asar, JH Yang… - …, 2021 - Elsevier
Depressed individuals suffer from effort-related motivational symptoms such as anergia and
fatigue, which are resistant to treatment with many common antidepressants. While drugs …

Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: suppression of high effort activity by the serotonin transport inhibitor …

RE Presby, RA Rotolo, EM Hurley, SM Ferrigno… - Pharmacology …, 2021 - Elsevier
Selective serotonin transport (SERT) inhibitors such as fluoxetine are the most commonly
prescribed treatments for depression. Although efficacious for many symptoms of depression, …

Behavioral activation, effort-based choice, and elasticity of demand for motivational stimuli: Basic and translational neuroscience approaches.

…, JH Yang, M Somerville, RA Rotolo, RE Presby - Motivation …, 2017 - psycnet.apa.org
Behavioral activation and effort-related processes are fundamental components of the
construct of motivation. Motivated behavior is often characterized by considerable vigor, …