… It was believed that the sick were possessed by demons and that health could be restored …
Efficacy (proof of effectiveness) became a requirement in 1962 with the Kefauver-Harris drug …

Orally administered reserpine is readily absorbed from the GI tract. During this process at
least a portion of the drug is metabolized by the intestinal mucosa and then presumably is …

… Van Dyke, DP Westfall and RE Stitzel, 1976, The effect of denervation upon the in vitro
incorporation of adenosine-8-3H into 3H-adenine nucleotides in the guinea-pig vas deferens, …

1 Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (65 mg
kg −1 ). Rabbits were rendered diabetic by injecting alloxan (100 mg kg −1 ) into the lateral …

A single injection of reserpine (1 mg kg ip) produced an increased susceptibility to minimal
electroshock seizures, as well as a decrease in whole brain levels of norepinephrine (NE), …

The change in norepinephrine (NE) content with age (from 2 days to 17 weeks old) was
examined in a variety of tissues from spontaneously hypertensive rats (SHR) and normotensive …

… Creveling and coworkers2 reported a successful application of this approach when they
prepared 3,4,j3-triacetylnorepinephrine and showed that it readily entered theCNS. In addition, …

In the present studies we have established that the perfused caudal artery from spontaneously
hypertensive(SH) rats re-sponds to pharmacological and physiological stimuli in a …

We have measured the catecholamine (CA) contents in hearts, mesenteric vasculature,
abdominal aorta, inferior vena cava, vasa deferentia and salivary glands from genetically …

The present study describes the influence of sex, age and drug pretreatment on drug
metabolism in four common strains of rats. Basal levels of activity of hepatic microsomal drug-…