Vertebrate vision begins with the absorption of light by rhodopsin, causing its 11-cis-retinal
Schiff base chromophore to photoisomerize into its all-trans form. All-trans-retinal is liberated …

… Rando has worked on the development of new kinds of mechanism-based inhibitors and
also discovered natural products which follow this mechanistic paradigm. His recent work has …

The enzyme responsible for conversion of all-trans-retinol into retinyl esters, the lecithin retinol
acyltransferase (LRAT) has been characterized at the molecular level. The cDNA coding …

Background: Aminoglycoside antibiotics interfere with ribosomal protein synthesis and with
intron splicing. Various lines of evidence suggest that RNA is the molecular target for …

Protein kinase C is activated by a 1,2-sn-diacylglycerol and phospholipid at low calcium
concentrations. Of the various phospholipids studied, phosphatidylserine has been shown to be …

… Wang and RR Rando, unpublished experiments) with similar affinities. In fact, the TAR RNA
… Wang and RR Rando, unpublished experiments). In this context, it is of further interest to …

RNA constructs prepared from wild-type and mutant (1555 G ) human mitochondrial 12S
RNA were studied with respect to their abilities to specifically bind aminoglycoside antibiotics. …

… Bernstein PS, Choi SY, Ho YC, Rando RR. Photoaffinity labeling of retinoic acid-binding
proteins. Proc NatAcadSci USA.1995;92:654-658. …

RPE65 is essential for the biosynthesis of 11-cis-retinal, the chromophore of rhodopsin.
Here, we show that the membrane-associated form (mRPE65) is triply palmitoylated and is a …

… 3H]-£j//-tra/zs-retinol plus [15]4C\-all-trans-Tctim\ was administered to either rats or frogs (Bernstein
& Rando, 1986). If isomerization occurs at the aldehyde level of oxidation, than half …