[HTML][HTML] Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

…, G Racagni, P Gass, MA Riva, R Molteni - Frontiers in cellular …, 2014 - frontiersin.org
Cytokines are key regulatory mediators involved in the host response to immunological
challenges, but also play a critical role in the communication between the immune and the …

Neuronal plasticity: a link between stress and mood disorders

F Calabrese, R Molteni, G Racagni, MA Riva - Psychoneuroendocrinology, 2009 - Elsevier
Although stress represents the major environmental element of susceptibility for mood
disorders, the relationship between stress and disease remains to be fully established. In the …

Stress during development: Impact on neuroplasticity and relevance to psychopathology

F Fumagalli, R Molteni, G Racagni, MA Riva - Progress in neurobiology, 2007 - Elsevier
Development represents a critical moment for shaping adult behavior and may set the stage
to disease vulnerability later in life. There is now compelling evidence that stressful …

A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

R Molteni, RJ Barnard, Z Ying, CK Roberts… - Neuroscience, 2002 - Elsevier
… 2 years of diet in the hippocampus (r 6mo =0.91, P<0.01; r 2yr =0.82, P<0.01; graph shown
for 6 months in Fig. 4B) but not in the cerebral cortex (r 6mo =0.44, P=0.23; r 2yr =0.37, P=0.27…

Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity

…, Z Ying, RR Roy, R Molteni… - Journal of …, 2002 - journals.physiology.org
We have investigated potential mechanisms by which exercise can promote changes in
neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary wheel …

Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function

GS Griesbach, DA Hovda, R Molteni, A Wu… - Neuroscience, 2004 - Elsevier
Voluntary exercise leads to an upregulation of brain-derived neurotrophic factor (BDNF)
and associated proteins involved in synaptic function. Activity-induced enhancement of …

Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor

R Molteni, A Wu, S Vaynman, Z Ying, RJ Barnard… - Neuroscience, 2004 - Elsevier
A diet high in total fat (HF) reduces hippocampal levels of brain-derived neurotrophic factor (BDNF),
a crucial modulator of synaptic plasticity, and a predictor of learning efficacy. We …

Serum and plasma BDNF levels in major depression: a replication study and meta-analyses

…, V Bagnardi, R Zanardini, R Molteni… - The World Journal of …, 2010 - Taylor & Francis
Objectives. Alterations of BDNF signalling in major depression (MD) are supported by studies
demonstrating decreased levels of the neurotrophin serum and plasma content in MD …

Differential effects of acute and chronic exercise on plasticity‐related genes in the rat hippocampus revealed by microarray

R Molteni, Z Ying… - European Journal of …, 2002 - Wiley Online Library
… According to this view, the elevated expression of the NMDA-R subunits resulting from
exercise could represent a downstream effect of exercise during acute phases. Probably, along …

Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis

…, PA Zunszain, M Horowitz, R Molteni… - Proceedings of the …, 2013 - National Acad Sciences
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular
mechanisms mediating these effects are poorly understood. Here we identify the …