User profiles for Randy D. Blakely

RD Blakely

Florida Atlantic University
Verified email at health.fau.edu
Cited by 36077

Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

T Pacholczyk, RD Blakely, SG Amara - Nature, 1991 - nature.com
AT most synapses, chemical signalling is terminated by a rapid reaccumulation of neurotransmitter
into presynaptic terminals 1–5 . Uptake systems for the biogenic amines are the initial …

Pharmacological profile of antidepressants and related compounds at human monoamine transporters

M Tatsumi, K Groshan, RD Blakely… - European journal of …, 1997 - Elsevier
… Author links open overlay panel Masahiko Tatsumi a b , Karen Groshan a , Randy D Blakely
… human norepinephrine transporter were provided to us by co-author Randy D. Blakely, Ph.…

Cloning and expression of a functional serotonin transporter from rat brain

RD Blakely, HE Berson, RT Fremeau Jr, MG Caron… - Nature, 1991 - nature.com
SELECTIVE antagonism of serotonin (5-hydroxytryptamine, 5HT) and noradrenaline transport
by antidepressants is a key element in the 'amine' hypothesis of affective disorders 1 . …

[HTML][HTML] The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters

CB Zhu, RD Blakely, WA Hewlett - Neuropsychopharmacology, 2006 - nature.com
Proinflammatory cytokines and serotonergic homeostasis have both been implicated in the
pathophysiology of major psychiatric disorders. We have demonstrated that activation of p38 …

[HTML][HTML] Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

…, I Biaggioni, RD Blakely, D Robertson - … England Journal of …, 2000 - Mass Medical Soc
Background Orthostatic intolerance is a syndrome characterized by lightheadedness, fatigue,
altered mentation, and syncope and associated with postural tachycardia and plasma …

A transient placental source of serotonin for the fetal forebrain

…, K Chen, ML Wilson, J King, JC Shih, RD Blakely… - Nature, 2011 - nature.com
Serotonin (5-hydroxytryptamine or 5-HT) is thought to regulate neurodevelopmental processes
through maternal–fetal interactions that have long-term mental health implications. It is …

Molecular physiology of norepinephrine and serotonin transporters

RD Blakely, LJ De Felice… - Journal of Experimental …, 1994 - journals.biologists.com
Cocaine- and antidepressant-sensitive norepinephrine and serotonin transporters (NETs and
SERTs) are closely related members of the Na+/Cl − transporter gene family, whose other …

[PDF][PDF] Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors

…, Q Han, L Jiang, C Li, SE Folstein, RD Blakely - The American Journal of …, 2005 - cell.com
Autism is a spectrum of neurodevelopmental disorders with a primarily genetic etiology
exhibiting deficits in (1) development of language and (2) social relationships and (3) patterns of …

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

…, DH Hall, DM Miller III, RD Blakely - Proceedings of the …, 2002 - National Acad Sciences
Parkinson's disease is a complex neurodegenerative disorder characterized by the death of
brain dopamine neurons. In mammals, dopamine neuronal degeneration can be triggered …

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α‐synuclein

…, JH Thomas, R Nass, RD Blakely… - Journal of …, 2003 - Wiley Online Library
Overexpression of human α‐synuclein in model systems, including cultured neurons, drosophila
and mice, leads to biochemical and pathological changes that mimic synucleopathies …