Aldehyde dehydrogenases (ALDHs) belong to a superfamily of enzymes that play a key role
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …

Background: The exact enzymatic mechanisms of ethanol oxidation in the brain are still
unclear. The catalase‐mediated oxidation of ethanol was demonstrated in rat brain using …

… of ethanol (levels of biogenic aldehydes may increase during ethanol metabolism) and
their ability to form isoquinoline-derived condensation products with their parent amine (Deitrich …

Acetaldehyde is suspected of being involved in the central mechanism of central nervous
system depression and addiction to ethanol, but in contrast to ethanol, it can not penetrate …

Ethanol (EtOH) in alcoholic beverages is consumed by a large number of individuals and its
elimination is primarily by oxidation. The role of nitric oxide (NO) in EtOH's effects is …

The putative contribution of brain acetaldehyde (AcH) to ethanol (EtOH) tolerance and
dependence (addiction) is reviewed. Although the role of AcH in EtOH addiction has been …

Ethanol consumption has effects on the central nervous system (CNS), manifesting as motor
incoordination, sleep induction (hypnosis), anxiety, amnesia, and the reinforcement or …

It was found that the accumulation of acetaldehyde produced from 50 mM ethanol in rat brain
homogenates takes place in all major brain regions. The velocity varied between 3.5 to 7.1 …

Aldehyde-oxidizing capacity has been measured in rat, monkey, and bovine brain with the
use of indole-3-acetaldehyde and nicotinamide adenine dinucleotide as substrates. The …

This book dissects the effects of ethanol on the major neurotransmitter systems affected by
ethanol and correlates these actions with the behavioral consequences. The subject is …