User profiles for Rose E. Presby

Rose Presby

Postdoc, The Scintillon Institute
Verified email at scintillon.org
Cited by 474

The psychopharmacology of effort-related decision making: dopamine, adenosine, and insights into the neurochemistry of motivation

…, S Ferrigno, JH Yang, RA Rotolo, RE Presby - Pharmacological …, 2018 - ASPET
Effort-based decision making is studied using tasks that offer choices between high-effort
options leading to more highly valued reinforcers versus low-effort/low-reward options. These …

Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: exertion of effort vs. anhedonia

…, A Ecevitoglu, C Carratala-Ros, RE Presby… - Brain Research …, 2022 - Elsevier
Instrumental behavior is a very complex and multifaceted process. Behavioral output during
instrumental performance is influenced by a variety of factors, including associative …

Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors

…, KR Beard, C Carratala-Ros, RE Presby… - …, 2024 - nature.com
People with depression and other neuropsychiatric disorders can experience motivational
dysfunctions such as fatigue and anergia, which involve reduced exertion of effort in goal-…

[HTML][HTML] The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and …

…, F Caria, R Schwartz, RE Presby… - Frontiers in …, 2019 - frontiersin.org
Animal studies of effort-based choice behavior are being used to model effort-related motivational
dysfunctions in humans. With these procedures, animals are offered a choice between …

Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and …

…, V Dragacevic, RE Presby, J Neri, E Robertson… - …, 2020 - Springer
Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may
be useful for treating motivational symptoms of depression and other disorders. Previous …

Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer …

JH Yang, RE Presby, AA Jarvie, RA Rotolo… - …, 2020 - Springer
Rationale Effort-based decision-making tasks offer animals choices between preferred
reinforcers that require high effort to obtain vs. low effort/low reward options. The neural …

The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions …

RA Rotolo, RE Presby, O Tracy, S Asar, JH Yang… - …, 2021 - Elsevier
Depressed individuals suffer from effort-related motivational symptoms such as anergia and
fatigue, which are resistant to treatment with many common antidepressants. While drugs …

Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort‐related choice responding

…, RA Rotolo, GA Edelstein, RE Presby… - Journal of the …, 2022 - Wiley Online Library
The dopamine‐depleting agent tetrabenazine alters effort‐based choice, suppressing food‐reinforced
behaviors with high response requirements, while increasing selection of low‐…

Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: suppression of high effort activity by the serotonin transport inhibitor …

RE Presby, RA Rotolo, EM Hurley, SM Ferrigno… - Pharmacology …, 2021 - Elsevier
Selective serotonin transport (SERT) inhibitors such as fluoxetine are the most commonly
prescribed treatments for depression. Although efficacious for many symptoms of depression, …

Behavioral activation, effort-based choice, and elasticity of demand for motivational stimuli: Basic and translational neuroscience approaches.

…, JH Yang, M Somerville, RA Rotolo, RE Presby - Motivation …, 2017 - psycnet.apa.org
Behavioral activation and effort-related processes are fundamental components of the
construct of motivation. Motivated behavior is often characterized by considerable vigor, …