Nitric oxide: first in a new class of neurotransmitters

SH Snyder - Science, 1992 - science.org
Nitric oxide (NO) is a simple gas with free radical chemical properties, but itis often confused
with the chemically distinct nitrous oxide, N2O, which is used as an anesthetic and is …

Nitric oxide, a novel neuronal messenger

DS Bredt, SH Snyder - Neuron, 1992 - Elsevier
… Low doses of quisqualate, which selectively destroy NOS neurons, reduce the toxicity of
subsequently administered NMDA(TM Dawson and SH Snyder, unpublished data). Thus, the …

Nitric oxide: a physiologic messenger molecule

DS Bredt, SH Snyder - Annual review of biochemistry, 1994 - annualreviews.org
… account for NOS reductase activity (DS Bredt and SH Snyder, in preparation). Presumably,
early in … together, one obtains NOS catalytic activity (DS Bredt and SH Snyder, in preparation). …

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

DS Bredt, SH Snyder - … of the National Academy of Sciences, 1990 - National Acad Sciences
Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of
macrophages and neutrophils, and influences of excitatory amino acids on cerebellar cyclic GMP. …

Opiate receptor: demonstration in nervous tissue

CB Pert, SH Snyder - Science, 1973 - science.org
… No metabolites of (SH]naloxone in rat brain and guinea pig intestine could be detected after
… The EDIO values for inhibition of stereospecific (SH]naloxone binding were defined as the …

Localization of nitric oxide synthase indicating a neural role for nitric oxide

DS Bredt, PM Hwang, SH Snyder - Nature, 1990 - nature.com
NITRIC oxide (NO), apparently identical to endothelium-derived relaxing factor in blood
vessels 1–3 , is also formed by cytotoxic macrophages 4,5 , in adrenal gland 6 and in brain …

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

I Creese, DR Burt, SH Snyder - Science, 1976 - science.org
Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in
mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs …

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

…, CE Glatt, C Lowenstein, RR Reed, SH Snyder - Nature, 1991 - nature.com
Nitric oxide is a messenger molecule, mediating the effect of endothelium-derived relaxing
factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in …

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

…, ED London, DS Bredt, SH Snyder - Proceedings of the …, 1991 - National Acad Sciences
Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels,
cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate …

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

DS Bredt, SH Snyder - … of the National Academy of Sciences, 1989 - National Acad Sciences
Nitric oxide, which mediates influences of numerous neurotransmitters and modulators on
vascular smooth muscle and leukocytes, can be formed in the brain from arginine by an …