International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family …

ML Halls, RAD Bathgate, SW Sutton… - Pharmacological …, 2015 - ASPET
Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate ligands for the
relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates pleiotropic …

A lab test and algorithms for identifying clients at risk for treatment failure

…, DW Smart, K Shimokawa, SW Sutton - Journal of clinical …, 2005 - Wiley Online Library
Many branches of medicine rely heavily on lab tests to monitor client treatment response
and use this information to modify their treatment. By contrast, those who offer psychological …

[HTML][HTML] Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81

…, J Wu, J Zhu, C Kuei, J Yu, J Shelton, SW Sutton… - Journal of Biological …, 2009 - ASBMB
Lactic acid is a well known metabolic by-product of intense exercise, particularly under anaerobic
conditions. Lactate is also a key source of energy and an important metabolic substrate…

Oxysterols direct B-cell migration through EBI2

…, J Wu, C Kuei, NS Mani, L Zhang, J Yu, SW Sutton… - Nature, 2011 - nature.com
EBI2 (also called GPR183) is an orphan G-protein-coupled receptor that is highly expressed
in spleen and upregulated upon Epstein–Barr-virus infection 1 . Recent studies indicated …

Cloning and characterization of human urocortin

CJ Donaldson, SW Sutton, MH Perrin… - …, 1996 - academic.oup.com
… Stable transfectants were selected based on resistance to G418 (1 mg/ml) and clones
expressing high CRF receptor levels were identified (Sutton and Vale, unpublished). These stable …

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

…, J Wu, X Xue, J Song, SW Sutton… - Proceedings of the …, 2014 - National Acad Sciences
The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating
IL-17–producing CD4 + Th17 T cells, which are essential in host defense and may play …

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat

…, LE Aluisio, IC Fraser, X Jiang, SW Sutton… - … of Pharmacology and …, 2009 - ASPET
Orexins are peptides produced by lateral hypothalamic neurons that exert a prominent role
in the maintenance of wakefulness by activating orexin-1 (OX1R) and orexin-2 (OX2R) …

Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat

…, RAD Bathgate, C Liu, GW Tregear, SW Sutton… - Neuroscience, 2007 - Elsevier
… Liu d , GW Tregear a b , SW Sutton d , AL Gundlach a c … RLX3 knock-out mice brains (Smith
CM, Ma S, Sutton SW, Gundlach AL, unpublished observations). Previous studies with an …

Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery

BL Roland, SW Sutton, SJ Wilson, L Luo, J Pyati… - …, 1999 - academic.oup.com
A recently identified neuropeptide with PRL-releasing capabilities binds to and activates a
previously known orphan G protein-coupled receptor, GPR10. We initiated a study to define …

Relaxin family peptide receptors–from orphans to therapeutic targets

…, RAD Bathgate, EN Unemori, SW Sutton… - Drug discovery today, 2008 - Elsevier
The relaxin family peptides have distinct expression profiles and physiological functions.
Several of them are the cognate ligands for 4 G-protein-coupled relaxin family peptide …