User profiles for S. D. Hall

Stephen Hall

Eli Lilly and Company
Verified email at lilly.com
Cited by 30968

Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective

…, J Snoeys, VV Upreti, M Zheng, SD Hall - Clinical …, 2015 - Wiley Online Library
The application of physiologically based pharmacokinetic (PBPK) modeling has developed
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …

Molecular and physical mechanisms of first-pass extraction

SD Hall, KE Thummel, PB Watkins, KS Lown… - Drug Metabolism and …, 1999 - ASPET
This is a report of a symposium held at the March 1997 meeting of the American Society for
Pharmacology and Therapeutics in San Diego. Our understanding of the events that control …

Overview of the genetics of alcohol use disorder

EA Tawa, SD Hall, FW Lohoff - Alcohol and alcoholism, 2016 - academic.oup.com
Aims Alcohol Use Disorder (AUD) is a chronic psychiatric illness characterized by harmful
drinking patterns leading to negative emotional, physical, and social ramifications. While the …

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

…, J Schuetz, PB Watkins, A Daly, SA Wrighton, SD Hall… - Nature …, 2001 - nature.com
… Reaction velocities and product ratios are presented as meanąsd Statistical comparisons
of mean data for different genotypes were performed by using a 2-sided, unpaired t-test with …

Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases …

…, PE Klotman, SA Nachman, SD Hall… - Clinical Infectious …, 2005 - academic.oup.com
Several lines of evidence point to kidney disease as an important complication of human
immunodeficiency virus (HIV) infection. Kidney function is abnormal in up to 30% of HIV-…

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a …

BA Ward, JC Gorski, DR Jones, SD Hall… - … of Pharmacology and …, 2003 - ASPET
We used human liver microsomes (HLMs) and recombinant cytochromes P450 (P450s) to
identify the routes of efavirenz metabolism and the P450s involved. In HLMs, efavirenz …

Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity

…, H Aljadhey, J Kesterson, MD Murray, SD Hall - Gastroenterology, 2004 - Elsevier
Background & Aims : Studies that evaluate the risk of hepatotoxicity from statins in hyperlipidemic
subjects with elevated baseline serum transaminases are lacking. We conducted a …

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7

…, J Eckstein, K Ruterbories, MA Hamman, SD Hall… - Drug Metabolism and …, 2002 - ASPET
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin

…, MA Hamman, EM O'Mara Jr, SD Hall - Clinical …, 1998 - Wiley Online Library
… Mean + SD blood concentration versus time curve of midazolam and tsN+nidazolam after
simultaneous intravenous and oral (n = 16) administration. Open circles represent mean blood …

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

…, SM Huang, LJ Lesko, SD Hall - Clinical …, 2001 - Wiley Online Library
… Gorski JC, Jones DR, Haehner-Daniels BD, Hamman MA, O’Mara EM Jr, Hall SD. The
contribution of intestinal and hepatic CYP3A to the interaction between midazolam and …