User profiles for S. D. Hall
Stephen HallEli Lilly and Company Verified email at lilly.com Cited by 30968 |
Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective
…, J Snoeys, VV Upreti, M Zheng, SD Hall - Clinical …, 2015 - Wiley Online Library
The application of physiologically based pharmacokinetic (PBPK) modeling has developed
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …
rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery …
Molecular and physical mechanisms of first-pass extraction
This is a report of a symposium held at the March 1997 meeting of the American Society for
Pharmacology and Therapeutics in San Diego. Our understanding of the events that control …
Pharmacology and Therapeutics in San Diego. Our understanding of the events that control …
Overview of the genetics of alcohol use disorder
EA Tawa, SD Hall, FW Lohoff - Alcohol and alcoholism, 2016 - academic.oup.com
Aims Alcohol Use Disorder (AUD) is a chronic psychiatric illness characterized by harmful
drinking patterns leading to negative emotional, physical, and social ramifications. While the …
drinking patterns leading to negative emotional, physical, and social ramifications. While the …
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
… Reaction velocities and product ratios are presented as meanąsd Statistical comparisons
of mean data for different genotypes were performed by using a 2-sided, unpaired t-test with …
of mean data for different genotypes were performed by using a 2-sided, unpaired t-test with …
Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases …
…, PE Klotman, SA Nachman, SD Hall… - Clinical Infectious …, 2005 - academic.oup.com
Several lines of evidence point to kidney disease as an important complication of human
immunodeficiency virus (HIV) infection. Kidney function is abnormal in up to 30% of HIV-…
immunodeficiency virus (HIV) infection. Kidney function is abnormal in up to 30% of HIV-…
The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a …
BA Ward, JC Gorski, DR Jones, SD Hall… - … of Pharmacology and …, 2003 - ASPET
We used human liver microsomes (HLMs) and recombinant cytochromes P450 (P450s) to
identify the routes of efavirenz metabolism and the P450s involved. In HLMs, efavirenz …
identify the routes of efavirenz metabolism and the P450s involved. In HLMs, efavirenz …
Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
Background & Aims : Studies that evaluate the risk of hepatotoxicity from statins in hyperlipidemic
subjects with elevated baseline serum transaminases are lacking. We conducted a …
subjects with elevated baseline serum transaminases are lacking. We conducted a …
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7
…, J Eckstein, K Ruterbories, MA Hamman, SD Hall… - Drug Metabolism and …, 2002 - ASPET
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …
oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent …
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin
…, MA Hamman, EM O'Mara Jr, SD Hall - Clinical …, 1998 - Wiley Online Library
… Mean + SD blood concentration versus time curve of midazolam and tsN+nidazolam after
simultaneous intravenous and oral (n = 16) administration. Open circles represent mean blood …
simultaneous intravenous and oral (n = 16) administration. Open circles represent mean blood …
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity
…, SM Huang, LJ Lesko, SD Hall - Clinical …, 2001 - Wiley Online Library
… Gorski JC, Jones DR, Haehner-Daniels BD, Hamman MA, O’Mara EM Jr, Hall SD. The
contribution of intestinal and hepatic CYP3A to the interaction between midazolam and …
contribution of intestinal and hepatic CYP3A to the interaction between midazolam and …