User profiles for S. Merighi

Stefania Merighi

University of Ferrara
Verified email at unife.it
Cited by 9341

Pharmacology of adenosine receptors: the state of the art

PA Borea, S Gessi, S Merighi… - Physiological …, 2018 - journals.physiology.org
… available AR-mediated drugs, in addition to adenosine itself, an A 2A AR agonist is used for
coronary artery imaging, and there is an A 2A AR antagonist for the treatment of Parkinson’s

Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?

PA Borea, S Gessi, S Merighi, K Varani - Trends in pharmacological …, 2016 - cell.com
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …

The A3 adenosine receptor: an enigmatic player in cell biology

S Gessi, S Merighi, K Varani, E Leung… - Pharmacology & …, 2008 - Elsevier
Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

A glance at adenosine receptors: novel target for antitumor therapy

S Merighi, P Mirandola, K Varani, S Gessi… - Pharmacology & …, 2003 - Elsevier
Adenosine can be released from a variety of cells throughout the body, as the result of increased
metabolic rates, in concentrations that can have a profound impact on the vasculature, …

The A3 adenosine receptor: history and perspectives

…, PG Baraldi, MA Tabrizi, S Merighi, S Gessi - Pharmacological …, 2015 - ASPET
By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular …

[HTML][HTML] Adenosine receptors and cancer

S Gessi, S Merighi, V Sacchetto, C Simioni… - Biochimica et Biophysica …, 2011 - Elsevier
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A 1 , A 2A , A 2B and …

Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human …

S Merighi, A Benini, P Mirandola, S Gessi, K Varani… - Molecular …, 2007 - ASPET
Frequent coffee consumption has been associated with a reduced risk of colorectal cancer
in a number of case-control studies. Coffee is a leading source of methylxanthines, such as …

[HTML][HTML] Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells

S Merighi, P Mirandola, D Milani, K Varani… - Journal of Investigative …, 2002 - Elsevier
Adenosine displays contradictory effects on cell growth: it improves cell proliferation, but it
may also induce apoptosis and impair cell survival. Following the pharmacologic …

[HTML][HTML] A2A adenosine receptors in human peripheral blood cells

S Gessi, K Varani, S Merighi, E Ongini… - British journal of …, 2000 - ncbi.nlm.nih.gov
Adenosine mediates a wide range of physiological functions by activation of at least four
cell surface receptors named A1, A2A, A2B and A3. Each receptor subtype has been cloned …

Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils

K Varani, S Gessi, S Merighi, V Iannotta… - British journal of …, 2002 - Wiley Online Library
… After 30 s, isotonicity was restored by adding 3 ml of a solution containing 0.6 M NaCl. Cells
were pelletted by centrifugation at 20C for 5 min at 250×g, suspended in 10 ml of the Krebs …