[Pyr1]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart: Vasoactive Mechanisms and Inotropic Action in Disease

JJ Maguire, MJ Kleinz, SL Pitkin, AP Davenport - Hypertension, 2009 - Am Heart Assoc
Apelin receptors, present on vascular smooth muscle cells, endothelium, and cardiomyocytes,
are activated by the family of apelin peptides to elicit cardiovascular effects in …

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function

SL Pitkin, JJ Maguire, TI Bonner, AP Davenport - Pharmacological reviews, 2010 - ASPET
A gene encoding a novel class a G-protein-coupled receptor was discovered in 1993 by
homology cloning and was called APJ. It was designated an “orphan” receptor until 1998, when …

Modulation of the apelin/APJ system in heart failure and atherosclerosis in man

SL Pitkin, JJ Maguire, RE Kuc… - British journal of …, 2010 - Wiley Online Library
Background and purpose: The aim of this study was to determine whether the apelin/APJ
system is altered in human cardiovascular disease by investigating whether the expression of …

Discovery of a competitive apelin receptor (APJ) antagonist

NJM Macaluso, SL Pitkin, JJ Maguire… - …, 2011 - Wiley Online Library
The apelin receptor (APJ) is a class AG‐protein‐coupled receptor (GPCR) and is a putative
target for the treatment of cardiovascular and metabolic diseases. Apelin‐13 (NH 2 ‐…

[PDF][PDF] Vasoactive Mechanisms and Inotropic Action in Disease

JJ Maguire, MJ Kleinz, SL Pitkin, AP Davenport - 2009 - Citeseer
Apelin receptors, present on vascular smooth muscle cells, endothelium, and cardiomyocytes,
are activated by the family of apelin peptides to elicit cardiovascular effects in …

[PDF][PDF] Isoform in the Human Heart

JJ Maguire, MJ Kleinz, SL Pitkin, AP Davenport - 2009 - academia.edu
Apelin receptors, present on vascular smooth muscle cells, endothelium, and cardiomyocytes,
are activated by the family of apelin peptides to elicit cardiovascular effects in …

Discovery and Characterisation of Linear and Cyclic Peptide Agonists of Apelins

AP Davenport, SL Pitkin, JJ Maguire, M Macaluso… - 2009 - Am Heart Assoc
The recently discovered apelin family of peptides mediate their actions by a single G-protein
coupled receptor, APJ. We have previously shown apelins have three major actions in the …

Early oral feeding versus delayed oral feeding in patients following total laryngectomy: a systematic review

A Hay, L Pitkin, R Mathew… - … —Head and Neck …, 2014 - journals.sagepub.com
Objectives: Assess the effects of early oral feeding in laryngectomy patients (before 7 days)
versus delayed or late oral feeding (7 days or later). Methods: We considered randomized …

[CITATION][C] Apelin Peptides, Synthesis and Metabolism

AP Davenport, SL Pitkin, JJ Maguire - Springer

[CITATION][C] Pyr1

J Maguire Janet, J Kleinz Matthias, L Pitkin Sarah… - Apelin-13 identified as the …, 2009