The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate
(S1P), in yeast, plants and mammals have shown that it has important functions. In higher …

The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized
as a critical regulator of many physiological and pathophysiological processes, including …

The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) can act intracellularly
independently of its cell surface receptors through unknown mechanisms. Sphingosine kinase 2 (…

The potent lipid mediator sphingosine-1-phosphate (S1P) is produced inside cells by two
closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a …

Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in
NF-κB signalling triggered by TNF-α 1 , 2 . Genetic evidence indicates that TRAF2 is …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cellular processes including proliferation, survival, and migration, as well as …

Sphingosine-1-phosphate (SPP) has diverse biological functions acting inside cells as a
second messenger to regulate proliferation and survival, and extracellularly, as a ligand for G …

The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), 1 formed by
phosphorylation of sphingosine catalyzed by sphingosine kinase (Fig. 1), is an important lipid …

The potent sphingolipid metabolite sphingosine 1-phosphate is produced by phosphorylation
of sphingosine catalyzed by sphingosine kinase (SphK) types 1 and 2. In contrast to pro-…

The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate
(S1P) play an important role in the regulation of cell proliferation, survival, and cell death…