Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice

KM Frick, SM Fernandez - Neurobiology of aging, 2003 - Elsevier
The present study tested whether environmental enrichment can reduce age-related spatial
reference memory deficits and alter synaptic protein levels in aged female mice. Female …

Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen …

SM Fernandez, MC Lewis, AS Pechenino… - Journal of …, 2008 - Soc Neuroscience
The extracellular signal-regulated kinase (ERK) pathway is critical for various forms of learning
and memory, and is activated by the potent estrogen 17β-estradiol (E 2 ). Here, we asked …

Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice

TJ Lambert, SM Fernandez, KM Frick - Neurobiology of learning and …, 2005 - Elsevier
Environmental enrichment paradigms that incorporate cognitive stimulation, exercise, and
motor learning benefit memory and synaptic plasticity across the rodent lifespan. However, the …

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

…, J Xu, N Carty, SM Fernandez… - Proceedings of the …, 2010 - National Acad Sciences
Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disorder. Early
in the pathophysiology of AD, synaptic function is disrupted by soluble Aβ oligomers, …

Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders

…, M Baum, CD Paspalas, SM Fernandez… - Pharmacological …, 2012 - ASPET
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific phosphatase that
modulates key signaling molecules involved in synaptic plasticity and neuronal function. …

Chronic oral estrogen affects memory and neurochemistry in middle-aged female mice.

SM Fernandez, KM Frick - Behavioral neuroscience, 2004 - psycnet.apa.org
This study tested whether chronic oral estrogen could improve memory and alter neural
plasticity in the hippocampus and neocortex of middle-aged female mice. Ovariectomized C57BL…

Behavioral training interferes with the ability of gonadal hormones to increase CA1 spine synapse density in ovariectomized female rats

KM Frick, SM Fernandez, JC Bennett… - European Journal of …, 2004 - Wiley Online Library
Estradiol benzoate (EB) has repeatedly been shown to increase hippocampal CA1 spine
synapse density in ovariectomized female rats. Although this increase has been assumed to …

A new approach to understanding the molecular mechanisms through which estrogens affect cognition

KM Frick, SM Fernandez, LL Harburger - Biochimica et Biophysica Acta …, 2010 - Elsevier
Traditional approaches to the study of hormones and cognition have been primarily observational
or correlational in nature. Because this work does not permit causal relationships to be …

[HTML][HTML] Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study

…, SE Fenton, F Mesmar, M Bondesson, MF Fernández… - Toxicology, 2021 - Elsevier
The 3T3-L1 murine pre-adipocyte line is an established cell culture model for screening
Metabolism Disrupting Chemicals (MDCs). Despite a need to accurately identify MDCs for …

[PDF][PDF] Cyberfeminism, racism, embodiment

M Fernandez - Domain errors, 2002 - refugia.net
… Tina Grillo and Stephanie M. Wildman have argued that white supremacy instills in many
whites the expectation of always being the center of attention. In their view, “When people who …