Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …

ATRIAL natriuretic peptide (ANP) is a polypeptide hormone whose effects include the induction
of diuresis, natriuresis and vasorelaxation 1 . One of the earliest events following binding …

Plasma membrane forms of guanylyl cyclase have been shown to function as natrluretlc
peptide receptors. We describe a new clone (GCC) encoding a guanylyl cyclase receptor for …

Atrial natriuretic peptide (ANP) binds directly to a plasma membrane form of guanylate cyclase
(GCA), stimulating the production of the second messenger cyclic GMP. We show that a …

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since
they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by …

Aim Routine control angiography is a valuable tool with high-sensitivity in detecting restenosis
after coronary stenting. However, the prognostic role of restenosis is still controversial. We …

Background & Aims: The most commonly lost gene products in colorectal carcinogenesis
include guanylin and uroguanylin, endogenous ligands for guanylyl cyclase C (GCC). Beyond …

Background Normalization in real-time qRT-PCR is necessary to compensate for experimental
variation. A popular normalization strategy employs reference gene(s), which may …

Allergens are diverse proteins from mammals, birds, arthropods, plants, and fungi. Allergens
associated with asthma (asthmagens) share a common protease activity that may directly …

Heat-stable enterotoxins (STa), which cause an acute secretory diarrhea, have been
suggested to mediate their actions through the guanylyl cyclase-C (GC-C) receptor. The GC-C …