The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene
encoding leptin 1 , an adipocyte-specific secreted protein which has profound effects on appetite …

Severely obese (ob/ob) mice are deficient in the adipocyte-derived hormone leptin, which
acts on the hypothalamus to control appetite and energy expenditure. The administration of …

Fig. 1 A frameshift mutation in MC4R is associated with dominantly inherited obesity. a, Half-filled
symbols indicate the heterozygote state of the two obese subjects in this pedigree. b, …

Human obesity has an inherited component, but in contrast to rodent obesity, precise genetic
defects have yet to be defined 1 . A mutation of carboxypeptidase E (CPE), an enzyme …

Recent studies in murine models suggest that resistin (also called Fizz3 [ 1 ]), a novel
cysteine-rich protein secreted by adipocytes, may represent the long-sought link between obesity …

Background Puberty, a complex biologic process involving sexual development, accelerated
linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone …

Background Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form
of obesity. However, the clinical spectrum and mode of inheritance have not been defined, …

The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and
their reversibility by leptin administration provide compelling evidence for the existence of …

Variants in the FTO (fat mass and obesity associated) gene are associated with increased
body mass index in humans. Here, we show by bioinformatics analysis that FTO shares …

To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …