User profiles for Steven W. Paugh
Steven W. PaughVerified email at vt.edu Cited by 7689 |
[HTML][HTML] Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
…, M Valentine, C Cheng, SW Paugh… - New England journal …, 2014 - Mass Medical Soc
Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …
[PDF][PDF] Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1-…
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1-…
“Inside-out” signaling of sphingosine-1-phosphate: therapeutic targets
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cellular processes including proliferation, survival, and migration, as well as …
critical cellular processes including proliferation, survival, and migration, as well as …
[HTML][HTML] Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Sphingolipids are ubiquitous components of cell membranes and their metabolites
ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important …
ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important …
[HTML][HTML] Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal
DR Gude, SE Alvarez, SW Paugh, P Mitra… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates myriad important cellular
processes, including growth, survival, cytoskeleton rearrangements, motility, and immunity. …
processes, including growth, survival, cytoskeleton rearrangements, motility, and immunity. …
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
SW Paugh, SG Payne, SE Barbour, S Milstien… - FEBS …, 2003 - Wiley Online Library
The potent immunosuppressive drug FTY720, a sphingosine analog, induces redistribution
of lymphocytes from circulation to secondary lymphoid tissues. FTY720 is phosphorylated in …
of lymphocytes from circulation to secondary lymphoid tissues. FTY720 is phosphorylated in …
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by
2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated …
2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated …
Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia
Importance With cure rates of childhood acute lymphoblastic leukemia (ALL) exceeding 85%,
there is a need to mitigate treatment toxicities that can compromise quality of life, including …
there is a need to mitigate treatment toxicities that can compromise quality of life, including …
[HTML][HTML] Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
Sphingosine-1-phosphate (S1P) is a potent lysolipid involved in a variety of biological
responses important for cancer progression. Therefore, we investigated the role of sphingosine …
responses important for cancer progression. Therefore, we investigated the role of sphingosine …
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL),
and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate …
and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate …