User profiles for Steven W. Paugh

Steven W. Paugh

Verified email at vt.edu
Cited by 7689

[HTML][HTML] Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

…, M Valentine, C Cheng, SW Paugh… - New England journal …, 2014 - Mass Medical Soc
Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …

[PDF][PDF] Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

…, NP Shah, M Devidas, G Reaman, M Smith, SW Paugh… - Cancer cell, 2012 - cell.com
Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1-…

“Inside-out” signaling of sphingosine-1-phosphate: therapeutic targets

K Takabe, SW Paugh, S Milstien, S Spiegel - Pharmacological reviews, 2008 - ASPET
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cellular processes including proliferation, survival, and migration, as well as …

[HTML][HTML] Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

NC Hait, CA Oskeritzian, SW Paugh, S Milstien… - … et Biophysica Acta (BBA …, 2006 - Elsevier
Sphingolipids are ubiquitous components of cell membranes and their metabolites
ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important …

[HTML][HTML] Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

DR Gude, SE Alvarez, SW Paugh, P Mitra… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates myriad important cellular
processes, including growth, survival, cytoskeleton rearrangements, motility, and immunity. …

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

SW Paugh, SG Payne, SE Barbour, S Milstien… - FEBS …, 2003 - Wiley Online Library
The potent immunosuppressive drug FTY720, a sphingosine analog, induces redistribution
of lymphocytes from circulation to secondary lymphoid tissues. FTY720 is phosphorylated in …

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

SW Paugh, BS Paugh, M Rahmani… - Blood, The Journal …, 2008 - ashpublications.org
The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by
2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated …

Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia

…, C Wing, SM Delaney, M Komatsu, SW Paugh… - Jama, 2015 - jamanetwork.com
Importance With cure rates of childhood acute lymphoblastic leukemia (ALL) exceeding 85%,
there is a need to mitigate treatment toxicities that can compromise quality of life, including …

[HTML][HTML] Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells

S Sarkar, M Maceyka, NC Hait, SW Paugh, H Sankala… - FEBS letters, 2005 - Elsevier
Sphingosine-1-phosphate (S1P) is a potent lysolipid involved in a variety of biological
responses important for cancer progression. Therefore, we investigated the role of sphingosine …

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

SW Paugh, EJ Bonten, D Savic, LB Ramsey… - Nature …, 2015 - nature.com
Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL),
and resistance to glucocorticoids in leukemia cells confers poor prognosis. To elucidate …