IL-1β-converting enzyme (ICE) cleaves pro-1L-1β to generate mature IL-1β. ICE is homologous
to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich…

Gliomas are the most common primary brain malignancies, with different degrees of
aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, ie, …

Interferon-γ-inducing factor (IGIF, interleukin-18) is a recently described cytokine that shares
structural features with the inter-leukin-1 (IL-1) family of proteins and functional properties …

The promise of nucleic acid based oligonucleotides as effective genetic therapies has been
held back by their low bioavailability and poor cellular uptake to target tissues upon systemic …

Background Type 17 helper T cells have been suggested to play a pathological role in psoriasis.
They secrete several proinflammatory cytokines, including interleukin-17A (also known …

Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-…

We report here that the Shigella invasion plasmid antigen (Ipa)B, which is sufficient to induce
apoptosis in macrophages, binds to caspase (Casp)-1, but not to Casp-2 or Casp-3. Casp-…

Caspases are intracellular proteases that mediate mammalian cell apoptosis. Caspase-1 (Casp-1)
is a unique caspase because it activates the proinflammatory cytokines interleukin (IL)…

BACKGROUND: In subjects with psoriasis, inflammation and epidermal hyperplasia are
thought to be controlled by T cell–derived cytokines. Evidence suggests that the T H 17 cell …

… MD i , Elizabeth Colston MD, PhD j , John Throup PhD j , Sudeep Kundu PhD j , Steve
Schoenfeld MD j , Misti Linaberry MPH j , Subhashis Banerjee MD j , Andrew Blauvelt MD, MBA k …