User profiles for T. D. Müller
Timo D. MüllerHelmholtz-Zentrum Munich Verified email at helmholtz-muenchen.de Cited by 14680 |
[HTML][HTML] Anti-obesity drug discovery: advances and challenges
Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …
[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-…
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-…
[HTML][HTML] Ghrelin
Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …
A guide to analysis of mouse energy metabolism
…, BB Kahn, SC Kozma, E Maratos-Flier, TD Müller… - Nature …, 2012 - nature.com
We present a consolidated view of the complexity and challenges of designing studies for
measurement of energy metabolism in mouse models, including a practical guide to the …
measurement of energy metabolism in mouse models, including a practical guide to the …
Animal models of obesity and diabetes mellitus
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
[HTML][HTML] Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants
…, A Scherag, S Friedel, G Brönner, TD Müller… - PloS one, 2007 - journals.plos.org
Background Obesity is a major health problem. Although heritability is substantial, genetic
mechanisms predisposing to obesity are not very well understood. We have performed a …
mechanisms predisposing to obesity are not very well understood. We have performed a …
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
We report the discovery of a new monomeric peptide that reduces body weight and diabetic
complications in rodent models of obesity by acting as an agonist at three key metabolically-…
complications in rodent models of obesity by acting as an agonist at three key metabolically-…
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
B Finan, T Ma, N Ottaway, TD Müller… - Science translational …, 2013 - science.org
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced
co-agonism at both of the receptors for the incretin hormones glucagon-like peptide-1 (…
co-agonism at both of the receptors for the incretin hormones glucagon-like peptide-1 (…
[HTML][HTML] Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and …
Meta-analyses of population-based genome-wide association studies (GWAS) in adults
have recently led to the detection of new genetic loci for obesity. Here we aimed to discover …
have recently led to the detection of new genetic loci for obesity. Here we aimed to discover …
The new biology and pharmacology of glucagon
TD Müller, B Finan, C Clemmensen… - Physiological …, 2017 - journals.physiology.org
In the last two decades we have witnessed sizable progress in defining the role of gastrointestinal
signals in the control of glucose and energy homeostasis. Specifically, the molecular …
signals in the control of glucose and energy homeostasis. Specifically, the molecular …