Proteinase-activated receptors are a recently described, novel family of seven-transmembrane
G-protein-coupled receptors. Rather then being stimulated through ligand receptor …

The high mobility group box‐1 (HMGB1), originally identified as an architectural nuclear
protein, exhibits an inflammatory cytokine‐like activity in the extracellular space. Here we show …

Using physiological, pharmacological, and gene disruption approaches, we demonstrate
that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic …

… ring sperm DNA, up to a final concentration of 0.1 mg/ml, were added to the hybridization
buffer containing 1.0 M NaCI, 10 mM Tris—HCI (pH 7.6), and 0.01% Triton X-100 (ST—T). The …

… We found no significant differences in fractions of regulatory T cells, NK cells, macrophages,
and myeloid-derived suppressor cells in bone marrow, peripheral blood, and spleen in …

In this study we examined the regulation of the stress-activated protein (SAP) kinases and
inhibitory κB kinases (IKKs) through stimulation of the novel G-protein-coupled receptor …

… The treatment of anti-HMGB1 mAb significantly increased the plasma troponin-T and …
Akiyama T, Yamazaki T. Myocardial interstitial norepinephrine and dihydroxyphenylglycol …

PAR-2 is the second member of the family of proteinase-activated receptors activated by
trypsin, tryptase, and several other serine proteinases. In order to evaluate the therapeutic …

To investigate the involvement of protease-activated receptor-2 (PAR-2) in allergic dermatitis,
we generated PAR-2-deficient (PAR-2 −/- ) mice. Ear thickness, contact hypersensitivity (…

Background and purpose: Up‐regulation of proteinase‐activated receptor‐2 (PAR2) is a
factor in a number of disease states and we have therefore examined the signalling pathways …