Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer

T Boutros, E Chevet, P Metrakos - Pharmacological reviews, 2008 - ASPET
Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1, DUSP1,
ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine dual-…

Interferon‐β is a potent promoter of nerve growth factor production by astrocytes

T Boutros, E Croze, VW Yong - Journal of neurochemistry, 1997 - Wiley Online Library
Recent clinical evidence has suggested that interferon‐β is efficacious in the treatment of
the demyelinating disease, multiple sclerosis. The mechanism of its efficacy remains unclear, …

Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF‐I and EGF

…, K Chen, L Fallavollita, T Boutros… - … journal of cancer, 2002 - Wiley Online Library
The regional lymph nodes draining primary breast carcinomas are generally the first site to
be invaded by disseminating tumor cells. The extent of lymph node involvement remains the …

[HTML][HTML] Proteomic analysis of tyrosine phosphorylation during human liver transplantation

A Emadali, PP Metrakos, F Kalantari, T Boutros… - Proteome science, 2007 - Springer
Background Ischemia-reperfusion (I/R) causes a dramatic reprogramming of cell metabolism
during liver transplantation and can be linked to an alteration of the phosphorylation level …

Transcriptional profiling of the human liver during the reperfusion phase of transplantation

T Boutros - 2010 - escholarship.mcgill.ca
Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1, DUSP1,
ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine dual-…

651 Characterization of the molecular machines involved in actin remodelling upon ischemia and reperfusion in human liver

A Emadali, T Boutros, B Muscatelli-Groux, G Tzimas… - Hepatology, 2003 - academia.edu
Background: Hepatic ischemia reperfusion injury (IR) is common during resection/transplantation
surgery. In addition to the local injury there is a systemic injury to other organs notably …

TMPRSS2-ERG Status Is Not Prognostic Following Prostate Cancer Radiotherapy: Implications for Fusion Status and DSB Repair

…, C Collins, J Squire, W Lam, TA Bismar, PC Boutros… - Clinical cancer …, 2013 - AACR
Background: Preclinical data suggest that TMPRSS2-ERG gene fusions, present in about 50%
of prostate cancers, may be a surrogate for DNA repair status and therefore a biomarker …

[HTML][HTML] Serrate RNA Effector Molecule (SRRT) Is Associated with Prostate Cancer Progression and Is a Predictor of Poor Prognosis in Lethal Prostate Cancer

…, R Alhajj, R Abdelsalam, S Ghosh, J Arbet, PC Boutros… - Cancers, 2023 - mdpi.com
Simple Summary This is the first study that has investigate the potential role of the SRRT
gene in prostate cancer using clinical samples. We found that high expression of SRRT was …

[HTML][HTML] Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry

…, AAA Awwad, RA Abdelsalam, PC Boutros… - Cancers, 2021 - mdpi.com
Simple Summary Prostate cancer is the most commonly diagnosed non-skin malignancy in
men. Numerous studies have been undertaken to explore the role that genomics plays in …

A synopsis of recent influential papers published in psychiatric journals from the Arab World

T Okasha, NN Boutros - Asian Journal of Psychiatry, 2010 - Elsevier
After a brief introduction to the Arab region, six recent and influential papers that have appeared
in one of the three leading psychiatry journals from the region are summarized. The first …