Rational and objectives. The reinstatement model is currently used in many laboratories to
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …

The objective of this article is to review data from studies that used a reinstatement model in
rats to elucidate the neural mechanisms underlying relapse to heroin and cocaine seeking …

A central problem in the treatment of drug addiction is high rates of relapse to drug use after
periods of forced or self-imposed abstinence. This relapse is often provoked by exposure to …

Rationale and objectives: Footshock stress reliably reinstates heroin seeking in rats, but the
time course of the development of this effect following drug withdrawal is not known. Here …

Studies in rats have shown that intermittent footshock stress reinstates drug seeking after
prolonged drug-free periods. Recently, we found that another environmental stressor, acute 1 d …

Rationale: Intermittent footshock reinstates drug-taking behavior in rats, but not behaviors
previously maintained by food reinforcers. Here we tested further the generality of this …

Repeated separation of rat pups from their mothers has been reported to increase behavioral
fearfulness and hypothalamic–pituitary–adrenal (HPA) response to stress. Recently, it was …

Drug addiction is associated with long-lasting neuronal adaptations including alterations in
dopamine and glutamate receptors in the brain reward system. Treatment strategies for …

Rational and objectives. Acute 1-day food deprivation stress reinstates heroin seeking in rats,
but the generality of this effect to other drugs, and its underlying mechanisms, are largely …

Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned
stimulus is first presented a number of times without other consequence. Disruption of LI has …