Extrapolation concepts for dealing with multiple contamination in environmental risk assessment

R Altenburger, WR Greco - … Environmental Assessment and …, 2009 - Wiley Online Library
… William R Greco … William R Greco … additivity, and independent action, also called response
addition or BLISS independence (Greco et al. 1995; for formula, assumptions see Table 1), …
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Application of a New Approach for the Quantitation of Drug Synergism to the Combination of cis-Diamminedichloroplatinum and 1-β-d-Arabinofuranosylcytosine

WR Greco, HS Park, YM Rustum - Cancer Research, 1990 - AACR
… ment, and parameters were estimated (KC Syracuse and WR Greco, Proc. Biopharm. Sect.
… distribution of the custom software package, SYNFIT, should be addressed to WR Greco. …
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Photofrin photodynamic therapy can significantly deplete or preserve oxygenation in human basal cell carcinomas during treatment, depending on fluence rate

…, JD Zollo, AS Dee, MT Cooper, DA Bellnier, WR Greco… - Cancer research, 2000 - AACR
At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically
deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute …
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Cyclosporin A is a broad-spectrum multidrug resistance modulator

…, SM Fricke, NA Williamson, WR Greco… - Clinical Cancer …, 2005 - AACR
Purpose: Overexpression of the multidrug resistance proteins P-glycoprotein (Pgp), multidrug
resistance protein (MRP-1), breast cancer resistance protein (BCRP), and lung resistance …
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An in Vivo Quantitative Structure-Activity Relationship for a Congeneric Series of Pyropheophorbide Derivatives as Photosensitizers for Photodynamic Therapy

BW Henderson, DA Bellnier, WR Greco, A Sharma… - Cancer research, 1997 - AACR
An in vivo quantitative structure-activity relationship (QSAR) study was carried out on a
congeneric series of pyropheophorbide photosensitizers to identify structural features critical for …
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Photodynamic therapy: a means to enhanced drug delivery to tumors

JW Snyder, WR Greco, DA Bellnier, L Vaughan… - Cancer research, 2003 - AACR
Using the photosensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a, we have
determined that photodynamic therapy (PDT) can be used to facilitate the delivery of …
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Population pharmacokinetics of the photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a in cancer patients

DA Bellnier, WR Greco, GM Loewen, H Nava… - Cancer research, 2003 - AACR
Photodynamic therapy is an effective and often curative treatment for certain solid tumors.
The porphyrin-based photosensitizer Photofrin, the only Food and Drug Administration-…
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Modeling of the Time-Dependency of in Vitro Drug Cytotoxicity and Resistance

LM Levasseur, HK Slocum, YM Rustum, WR Greco - Cancer Research, 1998 - AACR
… We thank Elva Winslow and Carol Wr/.osek for technical assistance and Drs. Amarnath …
Greco. WR. and Hakala. MT Biochemical pharmacology of lipophilic diaminopyrimidine …
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Initial clinical (phase I) trial of TLC D-99 (doxorubicin encapsulated in liposomes)

JW Cowens, PJ Creaven, WR Greco, DE Brenner… - Cancer Research, 1993 - AACR
A liposome-encapsulated form of doxorubicin (TLC D-99), which was shown in preclinical
toxicology to be less toxic to the gastrointestinal tract and myocardium than free doxorubicin, …
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Mild skin photosensitivity in cancer patients following injection of Photochlor (2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a; HPPH) for photodynamic therapy

DA Bellnier, WR Greco, H Nava, GM Loewen… - Cancer chemotherapy …, 2006 - Springer
Purpose: To measure skin photosensitivity in cancer patients infused with the new second-generation
photodynamic sensitizer Photochlor (2-[1-hexyloxyethyl]-2-devinyl …
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