General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

DE Mager, WJ Jusko - Journal of pharmacokinetics and …, 2001 - Springer
Drugs that bind with high affinity and to a significant extent (relative to dose) to a
pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear …

Comparison of four basic models of indirect pharmacodynamic responses

NL Dayneka, V Garg, WJ Jusko - Journal of pharmacokinetics and …, 1993 - Springer
… Kong, EA Ludwig, RL Slaughter, PM Distefano, J. Demasi, E. Middleton Jr., and WJ Jusko.
Pharmacokinetics … Cheng, and WJ Jusko. Two-compartment basophil cell trafficking model for …

[PDF][PDF] Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms

…, DZ D'Argenio, R Iyengar, WJ Jusko… - An NIH white …, 2011 - customsitesmedia.usc.edu
Background: This white paper arises from two workshops held at the NIH in 2008 and late
2010 with participation from academia, industry and government (http://meetings. nigms. nih. …

Pharmacokinetics of tacrolimus in liver transplant patients

WJ Jusko, W Piekoszewski… - Clinical …, 1995 - Wiley Online Library
Objective To characterize the pharmacokinetics of the immunosuppressive agent tacrolimus
(FK 506) in liver transplant patients. Methods Patients (n = 16) were assessed during and …

Characteristics of indirect pharmacodynamic models and applications to clinical drug responses

A Sharma, WJ Jusko - British journal of clinical pharmacology, 1998 - Wiley Online Library
This review describes four basic physiologic indirect pharmacodynamic response (IDR)
models which have been proposed to characterize the pharmacodynamics of drugs that act by …

Diversity of mechanism-based pharmacodynamic models

DE Mager, E Wyska, WJ Jusko - Drug metabolism and disposition, 2003 - ASPET
Pharmacodynamics is the study of the time course of pharmacological effects of drugs. The
field of pharmacodynamic modeling has made many advances, due in part to the relatively …

Physiologic indirect response models characterize diverse types of pharmacodynamic effects

WJ Jusko, HC Ko - Clinical Pharmacology & Therapeutics, 1994 - Wiley Online Library
A family of four basic physiologic indirect response models has been proposed to account
for the pharmacodynamics of drugs that act by way of inhibition or stimulation of the …

Contribution of cigarette smoking to cadmium accumulation in man

GP Lewis, LL Coughlin, WJ Jusko, S Hartz - The Lancet, 1972 - Elsevier
Cadmium, a non-essential, potentially toxic metal, accumulates in human tissues with
increasing age. Because many foods contain cadmium, the diet has been considered the major …

Plasma and tissue protein binding of drugs in pharmacokinetics

WJ Jusko, M Gretch - Drug metabolism reviews, 1976 - Taylor & Francis
The pervasive nature of drug-protein binding in pharmacology has attracted the attention of
investigators from many disciplines. Much of the pharmacology is, in the last analysis, …

Consensus document: therapeutic monitoring of tacrolimus (FK-506)

WJ Jusko, AW Thomson, J Fung… - Therapeutic drug …, 1995 - journals.lww.com
BACKGROUND Tacrolimus is a 23-membered ring compound with a molecular weight of
804 daltons (Fig. 1); it is a macrolide antibiotic that is highly lipophilic and poorly soluble in …