G protein-coupled receptor-dependent development of human frontal cortex

X Piao, RS Hill, A Bodell, BS Chang… - Science, 2004 - science.org
The mammalian cerebral cortex is characterized by complex patterns of anatomical and
functional areas that differ markedly between species, but the molecular basis for this functional …

[PDF][PDF] Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes

…, E Macosko, F Ginhoux, J Chen, RJM Franklin, X Piao… - Immunity, 2019 - cell.com
Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

…, AK Muthukumar, B Stevens, H Umemori, X Piao - The EMBO …, 2020 - embopress.org
Developmental synaptic remodeling is important for the formation of precise neural circuitry,
and its disruption has been linked to neurodevelopmental disorders such as autism and …

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

…, Z Jin, N Strokes, S Li, X Piao - Proceedings of the …, 2011 - National Acad Sciences
GPR56, an orphan G protein-coupled receptor (GPCR) from the family of adhesion GPCRs,
plays an indispensable role in cortical development and lamination. Mutations in the GPR56 …

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury

P Chen, X Piao, P Bonaldo - Acta neuropathologica, 2015 - Springer
The peripheral nervous system (PNS) has remarkable regenerative abilities after injury.
Successful PNS regeneration relies on both injured axons and non-neuronal cells, including …

International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors

…, DC Martinelli, KR Monk, MC Peeters, X Piao… - Pharmacological …, 2015 - ASPET
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

[PDF][PDF] Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids

…, M Haeussler, KB Hengen, RR Ransohoff, X Piao… - Cell Stem Cell, 2021 - cell.com
Microglia are resident macrophages in the brain that emerge in early development and respond
to the local environment by altering their molecular and phenotypic states. Fundamental …

[PDF][PDF] The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211

…, M Ghidinelli, ML Feltri, T Schöneberg, X Piao… - Neuron, 2015 - cell.com
Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous
system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons …

GPR56 regulates pial basement membrane integrity and cortical lamination

…, RO Hynes, CA Walsh, G Corfas, X Piao - Journal of …, 2008 - Soc Neuroscience
GPR56 is a member of the family of adhesion G-protein-coupled receptors that have a large
extracellular region containing a GPS (G-protein proteolytic site) domain. Loss-of-function …

[HTML][HTML] The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California

…, SP Oltman, MS Pantell, X Piao… - The Lancet Regional …, 2021 - thelancet.com
Introduction: Our understanding of the association between coronavirus disease 19 (COVID-19)
and preterm or early term birth among racially and ethnically diverse populations and …