User profiles for Ying-Xian Pan
Ying-Xian PanRutgers New Jersey Medical School Verified email at rutgers.edu Cited by 6621 |
Mu opioids and their receptors: evolution of a concept
GW Pasternak, YX Pan - Pharmacological reviews, 2013 - ASPET
Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …
problems. Although pain is the current focus, early use initially focused upon the treatment of …
Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters
YX Pan - DNA and cell biology, 2005 - liebertpub.com
Mu opioid receptors play an important role in mediating the actions of a class of opioids
including morphine and heroin. Binding and pharmacological studies have proposed several mu …
including morphine and heroin. Binding and pharmacological studies have proposed several mu …
Retention of heroin and morphine–6β–glucuronide analgesia in a new line of mice lacking exon 1 of MOR–1
Morphine produces analgesia by activating mu opioid receptors encoded by the MOR–1
gene. Although morphine–6β–glucuronide (M6G), heroin and 6–acetylmorphine also are …
gene. Although morphine–6β–glucuronide (M6G), heroin and 6–acetylmorphine also are …
Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2
…, SO Eans, JM Medina, J Xu, YX Pan… - Journal of medicinal …, 2016 - ACS Publications
Natural products found in Mitragyna speciosa, commonly known as kratom, represent
diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing …
diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing …
Structure-based design of bitopic ligands for the µ-opioid receptor
Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain management,
but are considered a major public health concern owing to their adverse side effects, …
but are considered a major public health concern owing to their adverse side effects, …
Identification and characterization of three new alternatively spliced μ-opioid receptor isoforms
YX Pan, J Xu, E Bolan, C Abbadie, A Chang… - Molecular …, 1999 - ASPET
We have identified four new μ-opiod receptor (MOR)-1 exons, indicating that the gene now
contains at least nine exons spanning more than 200 kilobases. Replacement of exon 4 by …
contains at least nine exons spanning more than 200 kilobases. Replacement of exon 4 by …
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas
In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour
establishment, progression and maintenance. We show that in glioblastoma multiforme (…
establishment, progression and maintenance. We show that in glioblastoma multiforme (…
[HTML][HTML] Endogenous opioid peptides and alternatively spliced mu opioid receptor seven transmembrane carboxyl-terminal variants
A Abrimian, T Kraft, YX Pan - International journal of molecular sciences, 2021 - mdpi.com
There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin,
all of which are derived from their precursors. These endogenous opioid …
all of which are derived from their precursors. These endogenous opioid …
Cloning and Characterization of a Mouse σ1 Receptor
YX Pan, J Mei, J Xu, BL Wan… - Journal of …, 1998 - Wiley Online Library
A cDNA clone (S2‐1a) isolated from a mouse brain cDNA library, using a guinea pig σ 1
cDNA as probe, has high homology to the predicted protein sequence of the guinea pig (88%) …
cDNA as probe, has high homology to the predicted protein sequence of the guinea pig (88%) …
Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
Pain remains a pervasive problem throughout medicine, transcending all specialty
boundaries. Despite the extraordinary insights into pain and its mechanisms over the past few …
boundaries. Despite the extraordinary insights into pain and its mechanisms over the past few …