User profiles for Ying-Xian Pan

Ying-Xian Pan

Rutgers New Jersey Medical School
Verified email at rutgers.edu
Cited by 6621

Mu opioids and their receptors: evolution of a concept

GW Pasternak, YX Pan - Pharmacological reviews, 2013 - ASPET
Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …

Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters

YX Pan - DNA and cell biology, 2005 - liebertpub.com
Mu opioid receptors play an important role in mediating the actions of a class of opioids
including morphine and heroin. Binding and pharmacological studies have proposed several mu …

Retention of heroin and morphine–6β–glucuronide analgesia in a new line of mice lacking exon 1 of MOR–1

AGP Schuller, MA King, J Zhang, E Bolan, YX Pan… - Nature …, 1999 - nature.com
Morphine produces analgesia by activating mu opioid receptors encoded by the MOR–1
gene. Although morphine–6β–glucuronide (M6G), heroin and 6–acetylmorphine also are …

Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2

…, SO Eans, JM Medina, J Xu, YX Pan… - Journal of medicinal …, 2016 - ACS Publications
Natural products found in Mitragyna speciosa, commonly known as kratom, represent
diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing …

Structure-based design of bitopic ligands for the µ-opioid receptor

…, SO Eans, MD Cameron, R Al-Hasani, YX Pan… - Nature, 2023 - nature.com
Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain management,
but are considered a major public health concern owing to their adverse side effects, …

Identification and characterization of three new alternatively spliced μ-opioid receptor isoforms

YX Pan, J Xu, E Bolan, C Abbadie, A Chang… - Molecular …, 1999 - ASPET
We have identified four new μ-opiod receptor (MOR)-1 exons, indicating that the gene now
contains at least nine exons spanning more than 200 kilobases. Replacement of exon 4 by …

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

…, GL Rocco, CW Brennan, EC Holland, YX Pan… - The EMBO …, 2011 - embopress.org
In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour
establishment, progression and maintenance. We show that in glioblastoma multiforme (…

[HTML][HTML] Endogenous opioid peptides and alternatively spliced mu opioid receptor seven transmembrane carboxyl-terminal variants

A Abrimian, T Kraft, YX Pan - International journal of molecular sciences, 2021 - mdpi.com
There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin,
all of which are derived from their precursors. These endogenous opioid …

Cloning and Characterization of a Mouse σ1 Receptor

YX Pan, J Mei, J Xu, BL Wan… - Journal of …, 1998 - Wiley Online Library
A cDNA clone (S2‐1a) isolated from a mouse brain cDNA library, using a guinea pig σ 1
cDNA as probe, has high homology to the predicted protein sequence of the guinea pig (88%) …

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

…, M Ansonoff, J Pintar, YX Pan… - Proceedings of the …, 2011 - National Acad Sciences
Pain remains a pervasive problem throughout medicine, transcending all specialty
boundaries. Despite the extraordinary insights into pain and its mechanisms over the past few …