Mammalian models of longevity are related primarily to caloric restriction and alterations in
metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 …

Recent data have demonstrated that caveolin, a major structural protein of caveolae,
negatively regulates signaling molecules localized to caveolae. The interaction of caveolin with …

Osteogenesis imperfecta (OI) is a heritable disorder, in both a dominant and recessive
manner, of connective tissue characterized by brittle bones, fractures and extraskeletal …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2 . It belongs
to the family of G protein–coupled receptors. It was originally identified, similar to the EP2 …

Caveolar localization of protein kinase C and the regulation of caveolar function by protein
kinase C are well known. This study was undertaken to examine whether caveolin subtypes …

The sympathetic nervous system is designed to respond to stress. Adenylyl cyclase (AC) is
the keystone of sympathetic transmission, yet its role in response to acute overload in the …

The changing relationship between stimuli and responses after prolonged receptor
stimulation is a general feature of hormonal signaling systems, termed desensitization. This …

Store-operated Ca 2+ entry (SOCE) is a major mechanism of Ca 2 + import from extracellular
to intracellular space, involving detection of Ca 2+ store depletion in endoplasmic reticulum …

Extracellular matrix (ECM) proteins create structural frameworks in tissues such as bone,
skin, tendon and cartilage etc. These connective tissues play important roles in the …

PGE, a potent vasodilator, plays a primary role in maintaining the patency of the ductus
arteriosus (DA). Genetic disruption of the PGE-specific receptor EP4, however, paradoxically …