Therapeutic targets: progress of their exploration and investigation of their characteristics

CJ Zheng, LY Han, CW Yap, ZL Ji, ZW Cao… - Pharmacological …, 2006 - ASPET
Modern drug discovery is primarily based on the search and subsequent testing of drug
candidates acting on a preselected therapeutic target. Progress in genomics, protein structure, …

TTD: therapeutic target database

X Chen, ZL Ji, YZ Chen - Nucleic acids research, 2002 - academic.oup.com
A number of proteins and nucleic acids have been explored as therapeutic targets. These
targets are subjects of interest in different areas of biomedical and pharmaceutical research …

SVM-Prot: web-based support vector machine software for functional classification of a protein from its primary sequence

CZ Cai, LY Han, ZL Ji, X Chen… - Nucleic acids research, 2003 - academic.oup.com
Prediction of protein function is of significance in studying biological processes. One approach
for function prediction is to classify a protein into functional family. Support vector machine …

Acoustic attenuation performance of circular expansion chambers with extended inlet/outlet

A Selamet, ZL Ji - Journal of Sound and Vibration, 1999 - Elsevier
The acoustic attenuation performance of circular expansion chambers with extended inlet/outlet
is investigated. Three approaches are employed to determine the transmission loss: (1) …

Enzyme family classification by support vector machines

CZ Cai, LY Han, ZL Ji, YZ Chen - Proteins: Structure, Function …, 2004 - Wiley Online Library
One approach for facilitating protein function prediction is to classify proteins into functional
families. Recent studies on the classification of G‐protein coupled receptors and other …

Briefing in family characteristics of microRNAs and their applications in cancer research

Q Wang, L Wei, X Guan, Y Wu, Q Zou, ZL Ji - Biochimica et Biophysica Acta …, 2014 - Elsevier
MicroRNAs (miRNAs) are endogenous, short, non-coding RNA molecules that are directly
involved in the post-transcriptional regulation of gene expression. Dysregulation of miRNAs is …

Drug Adverse Reaction Target Database (DART) Proteins Related to Adverse Drug Reactions

ZL Ji, LY Han, CW Yap, LZ Sun, X Chen, YZ Chen - Drug safety, 2003 - Springer
An adverse drug reaction (ADR) often results from interaction of a drug or its metabolites
with specific protein targets important in normal cellular function. Knowledge about these …

TiSGeD: a database for tissue-specific genes

SJ Xiao, C Zhang, Q Zou, ZL Ji - Bioinformatics, 2010 - academic.oup.com
The tissue-specific genes are a group of genes whose function and expression are preferred
in one or several tissues/cell types. Identification of these genes helps better understanding …

An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

…, S Tian, H Gao, W Miao, Y Liu, H Wang, C Yin, ZL Ji… - Cell, 2023 - cell.com
Macrophages are heterogeneous and play critical roles in development and disease, but
their diversity, function, and specification remain inadequately understood during human …

[HTML][HTML] PaGenBase: a pattern gene database for the global and dynamic understanding of gene function

JB Pan, SC Hu, D Shi, MC Cai, YB Li, Q Zou, ZL Ji - PloS one, 2013 - journals.plos.org
Pattern genes are a group of genes that have a modularized expression behavior under
serial physiological conditions. The identification of pattern genes will provide a path toward a …