Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A 1 , A 2A , A 2B , and A 3 . The A 2A and A 2B …

The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (GPCRs) mediates the important role of extracellular adenosine in many …

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments have …

To investigate the molecular mechanism for stereospecific binding of agonists to beta 2-adrenergic
receptors we used receptor models to identify potential binding sites for the beta-OH-…

CC chemokine receptor 2 (CCR2) is one of 19 members of the chemokine receptor
subfamily of human class A G-protein-coupled receptors. CCR2 is expressed on monocytes, …

Until now, more than 800 distinct G protein-coupled receptors (GPCRs) have been identified
in the human genome. The four subtypes of the adenosine receptor (A 1 , A 2A , A 2B and A …

… production induced by NECA and by 16−20 with apK B of 8.3 ± 0.6 (data not shown). This
value corresponds to literature data in which apA 2 value for CGS15943 of 8.0 ± 0.3 was …

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

G protein alpha subunits expose specific binding sites that allow for the sequential,
conformation-dependent binding of protein reaction partners, eg, G protein beta gamma dimers, …