User profiles for B. J. Gonzalez

Bryan J. González

Postdoctoral Research Scientist, Columbia University
Verified email at columbia.edu
Cited by 591

Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions

D Vaudry, BJ Gonzalez, M Basille, L Yon… - Pharmacological …, 2000 - ASPET
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide that
was first isolated from ovine hypothalamic extracts on the basis of its ability to stimulate cAMP …

[HTML][HTML] OMICtools: an informative directory for multi-omic data analysis

VJ Henry, AE Bandrowski, AS Pepin, BJ Gonzalez… - Database, 2014 - academic.oup.com
Recent advances in ‘omic’technologies have created unprecedented opportunities for
biological research, but current software and database resources are extremely fragmented. …

[PDF][PDF] Lymphocyte-derived exosomal microRNAs promote pancreatic β cell death and may contribute to type 1 diabetes development

…, F Mancarella, G Sebastiani, A Donda, BJ Gonzalez… - Cell metabolism, 2019 - cell.com
Type 1 diabetes is an autoimmune disease initiated by the invasion of pancreatic islets by
immune cells that selectively kill the β cells. We found that rodent and human T lymphocytes …

PACAP protects cerebellar granule neurons against oxidative stress‐induced apoptosis

…, H Vaudry, JC Beauvillain, BJ Gonzalez - European Journal of …, 2002 - Wiley Online Library
Oxidative stress, resulting from accumulation of reactive oxygen species, plays a critical role
in neuronal cell death associated with neurodegenerative diseases and stroke. In the …

[PDF][PDF] Combined inhibition of DYRK1A, SMAD, and trithorax pathways synergizes to induce robust replication in adult human beta cells

…, E Swartz, C Ackeifi, V Zlatanic, J Wilson, BJ González… - Cell metabolism, 2019 - cell.com
Small-molecule inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) induce
human beta cells to proliferate, generating a labeling index of 1.5%–3%. Here, we …

Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts

BJ Gonzalez, M Basille, D Vaudry, A Fournier… - Neuroscience, 1997 - Elsevier
High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) and its
receptors have been detected in the rat cerebellum during ontogenesis. In particular, PACAP …

Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death

…, A Fournier, H Vaudry, BJ Gonzalez - Proceedings of the …, 2002 - National Acad Sciences
Alcohol exposure during development can cause brain malformations and neurobehavioral
abnormalities. In view of the teratogenicity of ethanol, identification of molecules that could …

The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine …

D Vaudry, BJ Gonzalez, M Basille… - Proceedings of the …, 2000 - National Acad Sciences
Caspase-3 knockout mice exhibit thickening of the internal granule cell layer of the cerebellum.
Concurrently, it has been shown that intracerebral injection of pituitary adenylate cyclase-…

Prenatal alcohol exposure affects vasculature development in the neonatal brain

…, V Roy, A Laquerrière, BJ Gonzalez - Annals of …, 2012 - Wiley Online Library
Objective: In humans, antenatal alcohol exposure elicits various developmental disorders,
in particular in the brain. Numerous studies focus on the deleterious effects of alcohol on …

Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development

D Vaudry, BJ Gonzalez, M Basille… - Proceedings of the …, 1999 - National Acad Sciences
High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors
are present in the external granule cell layer of the rat cerebellum during postnatal …