[HTML][HTML] Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release
S Mahmoud, M Gharagozloo, C Simard, D Gris - Cells, 2019 - mdpi.com
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is, …
the central nervous system (CNS); however, residual glutamate in the extracellular space is, …
Flufenamic acid as an ion channel modulator
R Guinamard, C Simard, C Del Negro - Pharmacology & therapeutics, 2013 - Elsevier
… The single-channel conductance of GABA A and GABA C ranges from 10 to 30 pS. Its
current–voltage relationship is linear at the single channel level, yet exhibits weak outward …
current–voltage relationship is linear at the single channel level, yet exhibits weak outward …
[HTML][HTML] Elexacaftor–tezacaftor–ivacaftor for cystic fibrosis with a single Phe508del allele
…, N Nair, J Savage, C Simard… - … England Journal of …, 2019 - Mass Medical Soc
Background Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis
transmembrane conductance regulator (CFTR) protein, and nearly 90% of patients have at …
transmembrane conductance regulator (CFTR) protein, and nearly 90% of patients have at …
Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double …
…, SM Moskowitz, D Waltz, PR Sosnay, C Simard… - The Lancet, 2019 - thelancet.com
Background Cystic fibrosis transmembrane conductance regulator (CFTR) modulators correct
the basic defect caused by CFTR mutations. Improvements in health outcomes have been …
the basic defect caused by CFTR mutations. Improvements in health outcomes have been …
The non-selective monovalent cationic channels TRPM4 and TRPM5
R Guinamard, L Sallé, C Simard - Transient receptor potential channels, 2011 - Springer
… are highly variable in the C terminus. While TRPM6 and TRPM7 have the longest chain with
a kinase domain, TRPM4, TRPM5 and TRPM8 exhibit a very short C terminus. However, all …
a kinase domain, TRPM4, TRPM5 and TRPM8 exhibit a very short C terminus. However, all …
Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation
…, RL Mrad, S Plenchette, C Simard… - Proceedings of the …, 2008 - National Acad Sciences
The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated
in the activation of NF-κB by TNFα; however, genetic deletion of either cIAP1 or 2 did not …
in the activation of NF-κB by TNFα; however, genetic deletion of either cIAP1 or 2 did not …
[HTML][HTML] Tezacaftor–ivacaftor in patients with cystic fibrosis homozygous for Phe508del
…, CK Van Der Ent, A Moeller, C Simard… - New england journal …, 2017 - Mass Medical Soc
Background Combination treatment with the cystic fibrosis transmembrane conductance
regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target …
regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target …
Skeletal muscle adaptation to endurance training in patients with chronic obstructive pulmonary disease.
…, P LeBlanc, C Simard, J Jobin, C Bérubé… - American journal of …, 1996 - atsjournals.org
The purpose of this study was to evaluate the physiologic responses to endurance training
in patients with moderate to severe airflow obstruction by specifically looking at changes in …
in patients with moderate to severe airflow obstruction by specifically looking at changes in …
[HTML][HTML] VX-445–tezacaftor–ivacaftor in patients with cystic fibrosis and one or two Phe508del alleles
…, S Robertson, J Savage, C Simard… - New england journal …, 2018 - Mass Medical Soc
Background VX-445 is a next-generation cystic fibrosis transmembrane conductance regulator
(CFTR) corrector designed to restore Phe508del CFTR protein function in patients with …
(CFTR) corrector designed to restore Phe508del CFTR protein function in patients with …
Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD.
F Maltais, AA Simard, C Simard, J Jobin… - American journal of …, 1996 - atsjournals.org
Early lactic acidosis during exercise and abnormal skeletal muscle function have been
reported in chronic obstructive pulmonary disease (COPD) but a possible relationship between …
reported in chronic obstructive pulmonary disease (COPD) but a possible relationship between …