The nuclear receptor superfamily: the second decade

DJ Mangelsdorf, C Thummel, M Beato, P Herrlich… - Cell, 1995 - cell.com
We have identified and characterized two genes in Drosophila whose products are required
for activated RAS to signal with normal efficiency, but do not appear to effect signaling by …

The RXR heterodimers and orphan receptors

DJ Mangelsdorf, RM Evans - Cell, 1995 - Elsevier
… (Asterisk) The RARlRXR heterodimer is a potent repressor on a DRl (Mangelsdorf … limitations,
references for the various receptors are given in the overview by Mangelsdorf et al. (1995). …

Nuclear receptors and lipid physiology: opening the X-files

A Chawla, JJ Repa, RM Evans, DJ Mangelsdorf - Science, 2001 - science.org
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not
only nutritionally important but serve as precursors for ligands that bind to receptors in the …

[HTML][HTML] Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα

…, JMA Lobaccaro, RE Hammer, DJ Mangelsdorf - Cell, 1998 - cell.com
We demonstrate that mice lacking the oxysterol receptor, LXRα, lose their ability to respond
normally to dietary cholesterol and are unable to tolerate any amount of cholesterol in …

Identification of a nuclear receptor for bile acids

…, A Luk, MV Hull, KD Lustig, DJ Mangelsdorf… - Science, 1999 - science.org
Bile acids are essential for the solubilization and transport of dietary lipids and are the major
products of cholesterol catabolism. Results presented here show that bile acids are …

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

RA Heyman, DJ Mangelsdorf, JA Dyck, RB Stein… - Cell, 1992 - cell.com
… (CRBPII), which can be selectively activated by the RXRs and not the RARs, that
provided convincing functional discrimination between these two signaling pathways(Mangelsdorf

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

…, PJ Willy, TR Devi, JR Falck, DJ Mangelsdorf - Nature, 1996 - nature.com
CHOLESTEROL and its oxysterol congeners are important constitu-ents of cell membranes
and function as intermediates in several crucial biosynthetic pathways. These compounds …

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

…, U Borgmeyer, DJ Mangelsdorf… - Proceedings of the …, 1994 - National Acad Sciences
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR)
isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (…

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

…, MS Brown, JL Goldstein, DJ Mangelsdorf - Genes & …, 2000 - genesdev.cshlp.org
… , DJ Peet, and DJ Mangelsdorf, unpubl.). SREBP-2 mRNA levels were reduced by cholesterol
feeding as previously reported (Shimomura et al. 1997a) and did not show any consistent …

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

…, B Shan, RA Heyman, JM Dietschy, DJ Mangelsdorf - Science, 2000 - science.org
Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers
with retinoid X receptors (RXRs) and are activated by RXR agonists such as rexinoids. …