User profiles for D. N. Krause

Diana N. Krause

Professor of Pharmacology, University of California, Irvine
Verified email at uci.edu
Cited by 11302

CGRP as the target of new migraine therapies—successful translation from bench to clinic

…, KA Haanes, K Warfvinge, DN Krause - Nature Reviews …, 2018 - nature.com
Abstract Treatment of migraine is on the cusp of a new era with the development of drugs
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors

ML Dubocovich, P Delagrange, DN Krause… - Pharmacological …, 2010 - ASPET
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …

Influence of sex steroid hormones on cerebrovascular function

DN Krause, SP Duckles… - Journal of applied …, 2006 - journals.physiology.org
… and DN Krause, unpublished observations). As yet, there have been no reports of progesterone
receptors in cerebral vessels. However, these receptors are found in peripheral vascular …

Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels

C Stirone, SP Duckles, DN Krause, V Procaccio - Molecular pharmacology, 2005 - ASPET
We report here that estrogen (E 2 ) modulates mitochondrial function in the vasculature.
Mitochondrial dysfunction is implicated in the etiology of vascular disease; thus, vasoprotection …

Melatonin mediates two distinct responses in vascular smooth muscle

S Doolen, DN Krause, ML Dubocovich… - European journal of …, 1998 - Elsevier
… to explain this observation because similar results are observed whether melatonin is added
cumulatively or tested using a single concentration per artery segment (Doolen, Krause and …

Estrogen suppresses brain mitochondrial oxidative stress in female and male rats

A Razmara, SP Duckles, DN Krause, V Procaccio - Brain research, 2007 - Elsevier
Mitochondria are a major source of reactive oxygen species (ROS) and oxidative stress, key
contributors to aging and neurodegenerative disorders. We report that gonadal hormones …

MT2 melatonin receptors are present and functional in rat caudal artery

…, SP Duckles, ML Dubocovich, DN Krause - … of Pharmacology and …, 2002 - ASPET
In rat caudal artery, contraction to melatonin results primarily from activation of MT 1
melatonin receptors; however, the role of MT 2 melatonin receptors in vascular responses is …

Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries

GG Geary, DN Krause… - American Journal of …, 1998 - journals.physiology.org
Gender differences in the incidence of stroke and migraine appear to be related to circulating
levels of estrogen; however, the underlying mechanisms are not yet understood. Using …

Hormonal influences in migraine—interactions of oestrogen, oxytocin and CGRP

DN Krause, K Warfvinge, KA Haanes… - Nature Reviews …, 2021 - nature.com
Migraine is ranked as the second highest cause of disability worldwide and the first among
women aged 15–49 years. Overall, the incidence of migraine is threefold higher among …

Estrogen reduces mouse cerebral artery tone through endothelial NOS-and cyclooxygenase-dependent mechanisms

GG Geary, DN Krause… - American Journal of …, 2000 - journals.physiology.org
Gender and estrogen status are known to influence the incidence and severity of cerebrovascular
disease. The vasoprotective effects of estrogen are thought to include both nitric oxide-…