A deficiency in the noradrenergic system of the brain, originating largely from cells in the
locus coeruleus (LC), is theorized to play a critical role in the progression of a family of …

… 27 Colpaert. FC. Narcotic cue. narcotic analgesia and the tolerance problem: the regulation
… and Colpaert, FC, Increase of substance P in primary afferent nerves during chronic pain, …

Areas of neurobiological interest are identified towards which drug discrimination (DD) studies
have made important contributions. DD allows ligand actions to be analyzed at the whole …

Six pairs of female squirrel monkeys were given a daily intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) for 9–14 days, beginning the same day on …

The experiments characterized the dose- and time-dependence of parkinsonian motor
signs induced by reserpine in rats and a standardized system of manipulation of animals, …

Endothelium injury is a primary event in atherogenesis, which is followed by monocyte infiltration,
macrophage differentiation, and smooth muscle cell migration. Peroxisome proliferator-…

Background and purpose: Activation of post‐synaptic 5‐HT 1A receptors may provide
enhanced therapy against depression. We describe the signal transduction profile of F15599, a …

We report the discovery of F 13640 and evidence suggesting this agent to produce powerful,
broad-spectrum analgesia by novel molecular and neuroadaptative mechanisms. F 13640 …

The experiments described here were aimed at further validating adjuvant arthritis as an
animal model of chronic pain. It was found that the relative oral intake of a 0.008 mg/ml solution …

The study examined the validity of oral fentanyl self-administration (FSA) as a measure of the
chronic nociceptive pain that develops in rats with adjuvant arthritis independently of acute …